1. WASTE WATER TREATMENT FOR RITONAVIR PRODUCTION PLANT Presented by Wang Dong Mei July 8, 2000

2. GENERAL LAYOUT OF PHARMECUTICAL FACTORY Chemical Process Tanks Air Emissions Sewer Discharge Hazardous Waste Tank Direct Discharge Laboratory Storm Water Transportation Storage Construction

3. PROBLEM STATEMENT High concentration of biochemical oxygen demand (BOD): 9,100 mg/l High concentration of chemical oxygen demand (COD): 85,290 mg/l High concentration of total organic carbon (TOC): 23980 mg/l High concentration of total nitrogen (TN): 900 mg/l High concentration of total solid (TS): 10,480 mg/l

4. DESIGN OBJECTIVES Removal of BOD Removal of COD Removal of TOC Removal of TN Removal of TS

5. RATIONAL APPROACH Primary treatment: physical unit operations Secondary treatment: chemical and biological unit process Tertiary treatment: combinations of physical, chemical and biological processes

6. PRIMARY TREATMENT Screening: to protect pumps, valves, pipelines, and other appurtenances from damage or clogging by rags and large objects Grit chamber: to remove grit, sand, and gravel, usually following screening Equalization tank: equalization of flow and loadings, neutralization pH

7. PRIMARY TREATMENT Influent ScreensGrit Chamber Equalization & Neutralization Tank Primary Sediment Tank

8. SECONDARY TREATMENT Flocculation and coagulation: to apply chemical mixing to increase the removal of COD Primary sedimentation: to remove chemical precipitation, settle-able solids, and particular matter Activated sludge: to remove BOD by microorganism degradation Secondary sedimentation: to remove settable-able solids

9. SECONDARY TREATMENT Flocculation and Coagulation Activated Sludge Pond Primary Sedimentation Secondary Sedimentation

10. TERTIARY TREATMENT Two-step biological nitrification/denitrification: Removal of nitrogen by using trickling filters Ammonia is converted aerobically to nitrate(NO 3 - ) (nitrification) in the first step Nitrates are converted to nitrogen gas (denitrification)

11. TRICKLING FILTER

12. DISINFECTION Disinfect pathogen or other organisms by applying Cl 2 Chlorate contact tank

13. SLUDGE PROCESSING Sludge thickening Sludge stabilization Anaerobic sludge digestion Gas production and collection Sludge disinfection Sludge dewatering Land fill

14. LAYOUT OF THE PLANT

15. WATER QUALITY OF THE EFFLUENT