Final Height Following Growth Hormone Treatment of Idiopathic Growth Hormone Deficiency in KIGS Wayne S Cutfield, Anders Lindberg, Pierre Chatelain, David A Price, Kerstin Albertsson-Wikland, Patrick Wilton, and Michael B Ranke on behalf of the KIGS International Board KIGS 10 Year Book, 1999

W Cutfield - KIGS 10 Year Book, 1999 Baseline characteristics of patients with idiopathic GHD prior to commencement of GH therapy a MPH, mid-parental height; SDS, standard deviation score * p<0.01 a Values expressed as medians (10th - 90th percentiles)

W Cutfield - KIGS 10 Year Book, 1999 GH treatment regimens and auxological characteristics of patients with idiopathic GHD who have achieved final height a MPH, mid-parental height; SDS, standard deviation score * p<0.01 a Values expressed as medians (10th - 90th percentiles)

W Cutfield - KIGS 10 Year Book, 1999 Final height achieved by male subjects with idiopathic growth hormone deficiency (1/2) Means ( ), +2 SD ( ), and -4 SD ( ).

Final height achieved by female subjects with idiopathic growth hormone deficiency W Cutfield - KIGS 10 Year Book, 1999 (2/2) Means ( ), +2 SD ( ), and -4 SD ( ).

W Cutfield - KIGS 10 Year Book, 1999 Comparison of patients with spontaneous onset of puberty and those with induced puberty for whom auxological data were available at onset of puberty (medians) MPH, mid-parental height; SDS, standard deviation score, * p<0.01

MPH, mid-parental height ; NS, not significant W Cutfield - KIGS 10 Year Book, 1999 Relation of pretreatment and treatment variables to final height based on simple linear correlations

Influence of mid-parental height on final height in the National Cooperative Growth Study (NCGS) a and in KIGS subjects W Cutfield - KIGS 10 Year Book, 1999 a NCGS data from Blethen et al (1997)

Difference in height SDS between idiopathic GH- deficient male subjects with induced or with spontaneous puberty at start of GH treatment, onset of puberty and final height W Cutfield - KIGS 10 Year Book, 1999 Spontaneous Induced GH start Spontaneous Induced Pubertal onset Spontaneous Induced Final height Height (SDS) Data are shown as 25th and 75 percentiles (box plots), medians (rules) and means (dots), with whiskers at the 10th and 90th percentiles

Difference in height SDS between idiopathic GH- deficient female subjects with induced or with spontaneous puberty at start of GH treatment, onset of puberty and final height W Cutfield - KIGS 10 Year Book, 1999 Spontaneous Induced GH start Spontaneous Induced Pubertal onset Spontaneous Induced Final height Height (SDS) Data are shown as 25th and 75 percentiles (box plots), medians (rules) and means (dots), with whiskers at the 10th and 90th percentiles