14.20 Signals from the paraxial mesoderm induce pronephros formation in the intermediate mesoderm of the chick embryo (Part 1)

Slides:

Advertisements

Similar presentations

Bio Section III Organogenesis Paraxial and Intermediate Mesoderm Gilbert 9e – Chapter 11.

Advertisements

Chapter 16- Tetrapod limb development “It is one thing to differentiate the chondrocytes and osteocytes that synthesize the cartilage and bone matrices;

INTRODUCTION TO MOLECULAR REGULATION & SIGNALING

Paraxial and Intermediate Mesoderm Formation of Somites Muscle and bone formation Intermediate mesoderm: Kidney formation.

“It is not birth, marriage or death, but gastrulation which is truly the most important time in your life.” Lewis Wolpert.

Cell Differentiation: Cell interactions in Development

Neural Crest Cells The cells of the neural crest migrate to generate many cell types: 1)the neurons and glial cells of the sensory, sympathetic and parasympathetic.

Cell-Cell Signaling Inductive Interactions. Induction: proximate interactions Close range interactions Inducer –Tissue doing the inducing –Emits a signal.

Signals in frog embryos How can we identify developmental signaling pathways? How do other vertebrate embryos develop?

Bio Section I Introduction to Developmental Biology

Kidney Development Chris Campbell Oct 28, 2014 What does a mature kidney look like? How does it develop? Transcription factors.

Somitigenesis, Anterior-Posterior specification Segmentation in Vertebrates: SOMITIGENESIS.

Chapter 14- Mesoderm-paraxial and intermediate Recall lineages: Fig Fig mesoderm lineages Fig mesoderm lineages in chick 24hr 48hr.

Ch16 Limb Formation. Limb Disc surrounded by Limb Field.

Allantois / placenta. Figure 2.22 The Amniote Chick Egg, Showing the Membranes Enfolding the 7-Day Embryo Chick Embryo.

Chapter 14- Mesoderm-paraxial and intermediate

Notogenesis, neurulation, somitogenesis

Cell-cell Communications in Development

Development of the nervous system – 2

Nephrogenesis Maria E. Ferris, MD, MPH September 2001.

“It is not birth, marriage or death, but gastrulation which is truly the most important time in your life.” Lewis Wolpert.

Introduction to Developmental Biology

Cell-Cell Communication  Modes of Cellular Adhesion  Movement of Cells/Tissues  We’re here, now what? Cell Signaling and differentiation  Contacting.

Developmental stage-specific biphasic roles of Wnt signaling in cardiomyogenesis and hematopoiesis (Atsuhiko T. Naito et al, 2006, Development)

Χ Υ B. Η ανάπτυξη των γονάδων στο ανθρώπινο έμβρυο αρχίζει την 32η ημέρα της κύησης. Δημιουργούνται οι γοναδικές ακρολοφίες στην κοιλιακή επιφάνεια.

BIO624: Developmental Genetics GASTRULATION PART I Suk-Won Jin, Ph.D.

Paraxial and Intermediate Mesoderm Lange BIOL 370 – Developmental Biology Topic #14.

ANIMAL DEVELOPMENT CH. 47 MECHANISMS OF MORPHOGENESIS AND CELL FATE 1.

Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm Lindsley R.C. et al, Development (2006)

Copyright © 2005 Brooks/Cole — Thomson Learning Biology, Seventh Edition Solomon Berg Martin Chapter 16 Genes and Development.

Integrating and Controlling Signals By Kimmie Bui.

Paraxial and Intermediate Mesoderm. Mesodermal Regions Into what five regions do we subdivide the mesoderm? –prechordal plate mesoderm –chordamesoderm.

BIO624: Developmental Genetics GASTRULATION PART II Suk-Won Jin, Ph.D.

Development of the Tetrapod Limb - Placement on the Axis, Forelimb Vs

Intermediate Mesoderm: Kidney and Gonad Development Gilbert: Chapter 14, 17.

Vertebrate Embryonic Patterning 6 Limb Formation.

Morphogenesis Differentiation – 4 Cell-cell communication Lecture 12 BSE

The fate of neural crest cells The mesoderm Sex determination

Chapter 1: Skeletal Morphogenesis and Embryonic Development Yingzi Yang.

Page 1 What is TGF-β —Creative BioMart. Page 2 The transforming growth facor beta (TGF-β) superfamily is a large family of growth factors named after.

In vitro branching tubulogenesis: Implications for developmental and cystic disorders, nephron number, renal repair, and nephron engineering Hiroyuki.

Paraxial and Intermediate mesoderm

Stem cells in the embryonic kidney

Anatómiai, Szövet- és Fejlődéstani Intézet

Development of the kidney - malformations

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

The fate of neural crest cells

Stage 10 Human Embryo (~ 22 Days)

Paraxial mesoderm and somitogenesis

Bio 3411 Lecture IV. Mechanisms of Neural Development

Limb development Dr. Nandor Nagy Semmelweis University,

Volume 4, Issue 1, Pages (January 2003)

Paola Romagnani, Benjamin D. Humphreys Kidney International

Seppo Vainio, Ulrich Müller Cell

FGF23–parathyroid interaction: implications in chronic kidney disease

Male Germ Cell Specification and Differentiation

Kidney Development: Core Curriculum 2011

Vertebrate Development: Wnt Signals at the Crest

Figure 1 Key embryogenic decision points during kidney development

Volume 61, Issue 3, Pages (March 2002)

Molecular Mechanisms Regulating Hair Follicle Development

Volume 22, Issue 6, Pages (June 2012)

Volume 89, Issue 1, Pages (April 1997)

Expression of Hox genes, ALK5, GDF11 and ALK4 in Alk5−/− mutants.

Epithelial Mesenchymal Interactions in Cancer and Development

Kelsey J. Roberts, Aaron M. Kershner, Philip A. Beachy Cancer Cell

Directing Lung Endoderm Differentiation in Pluripotent Stem Cells

Volume 119, Issue 4, Pages (October 2000)

Volume 9, Issue 2, Pages (August 2005)

Growing a new human kidney

Presentation transcript:

14.20 Signals from the paraxial mesoderm induce pronephros formation in the intermediate mesoderm of the chick embryo (Part 1)

14.20 Signals from the paraxial mesoderm induce pronephros formation in the intermediate mesoderm of the chick embryo (Part 2) Lim1 expression in E8

14.21 General scheme of development in the vertebrate kidney (Part 1)

14.22 Reciprocal induction in the development of the mammalian kidney

14.23 Kidney induction observed in vitro

The mechanisms of reciprocal induction The induction of metanephros is a dialogue between the ureteric buds and the metanephrogenic mesenchyme and its devided into 8 major steps. Only the metanephrogenic mesenchyme has the competence to respond to the ureteric bud and form kidney tubules. The positional specification of the metanephrogenic mesenchyme is negatively regulated by two trancrisption factors: Foxc1 and Foxc2. The permanent kidney-forming metanephrogenic mesenchyme is specified by the genes of the Hox11 paralogue group. The competence to respond to ureteric bud inducers is regulated by a tumor suppressor gene, WT1.

14.24 Ureteric bud growth is dependent on GDNF and its receptors (Part 1) Pax2 and Hox11 GDNF (glial cell line derived neurotrophic factor)

The 3 rd signal in kidney development is sent from the ureteric bud to the metanephrogenic mesenchyme. Fgf2 and BMP7: inhibit apoptosis and maintain the synthesis of WT1. The ureteric bud converts metanephrogenic mesenchyme into epithelium. The transition from mesenchymal to epithelial is mediated by several molecules, including Pax2, Wnt6 and Wnt9. Wnt4 is very important for the formation of the nephron.

14.25 Wnts are critical for kidney development

Once induced, the mesenchyme begins to secrete Wnt4. Wnt4 acts in a autocrine fashion to complete the transition from mesenchymal mass to epithelium. One molecule that may be involved in the transition from aggregated mesenchyme to nephrons is Lim1 which are found around the ureteric bud.

14.26 Lim1 expression (dark stain) in a 19-day embryonic mouse kidney