Lectures inEarly Breast Cancer A PowerPoint slide set based on images from: Lectures in Early Breast Cancer Part 3: Adjuvant Therapy in Early Breast Cancer

Lectures inEarly Breast Cancer Reproduced with permission from the EBCTCG (2005).

Lectures inEarly Breast Cancer Participants (n=10,386) had either oestrogen receptor (ER)-positive or ER-unknown disease: 20% ER-unknown, 30% node-positive. Error bars are ±1SE. Reproduced with permission from the EBCTCG (2005).

Lectures inEarly Breast Cancer *Odds ratio calculated instead of hazard ratio. A, anastrozole; T, tamoxifen; HR +, hormone-receptor-positive. Reproduced with permission from Howell et al. (2005).

Lectures inEarly Breast Cancer The second non-breast cancers included endometrial cancer (6 patients in the letrozole group and 15 patients in the tamoxifen group), colon cancer (8 and 13 patients, respectively), lung cancer (5 and 8 patients), ovarian cancer (4 and 8 patients), renal cancer (4 and 8 patients) and other types (42 and 30 patients). Causes of death without a prior cancer event included cerebrovascular accident (7 patients in the letrozole group and 1 patient in the tamoxifen group), thromboembolic event (2 patients in each group), cardiac causes (13 and 6 patients, respectively), sudden death of unknown cause (10 patients in each group), and other causes (23 and 19 patients, respectively). Patients with multiple causes of death were classified as having ‘other causes’. Two-sided p values for the cumulative incidence were calculated with the use of Gray's test. Reproduced with permission from Thurlimann et al. (2005).

Lectures inEarly Breast Cancer *A disease-free survival event was defined as the first of any of the following events: any breast-cancer recurrence; a new invasive cancer in the contralateral breast; a second non-breast cancer; or death without a prior cancer event. Reproduced with permission from Thurlimann et al. (2005).

Lectures inEarly Breast Cancer Reproduced with permission from Jakesz et al. (2005).

Lectures inEarly Breast Cancer Data taken from Coombes et al. (2006) and Kaufman et al. (2006).

Lectures inEarly Breast Cancer Of breast cancer recurrences, 60% occur more than 5 years postsurgery. Annual risk of late recurrence is particularly high in oestrogen-receptor-positive (ER + ) tumours. PgR +, progesterone-receptor-positive. Reproduced with permission from Saphner et al. (1996).

Lectures inEarly Breast Cancer Reproduced from the EBCTCG (2005).

Lectures inEarly Breast Cancer Reproduced with permission from Ingle et al. (2001).

Lectures inEarly Breast Cancer *In favour of tamoxifen. † n=2229 for anastrozole, 2236 for tamoxifen, excluding patients with hysterectomy at baseline, recorded at any time. ‡ Patients with one or more fractures occurring at any time before recurrence (includes patients no longer receiving treatment). § Patients may have had one or more fractures at difference sites. Reproduced with permission from Howell et al. (2005).

Lectures inEarly Breast Cancer Reproduced with permission from Dowsett et al. (2005).

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