Interferons Type I IFN IFN-ω IFN-  IFN-  IFN-  IFN-  IFN-  IFN-  Type II IFN IFN-  Type III IFN IFN-   IL  B  IFN-   IL  IFN-   IL.

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Presentation transcript:

Interferons Type I IFN IFN-ω IFN-  IFN-  IFN-  IFN-  IFN-  IFN-  Type II IFN IFN-  Type III IFN IFN-   IL  B  IFN-   IL  IFN-   IL  A  Reza Khorooshi

IKK Nucleus Endosome promoter MDA5 dsRNA RIG-I dsRNA STING dsDNA dsRNA ssRNA CPG DNA LPS Exogenous stimuli: Virus Bacteria Endogenous stimuli: Molecules released upon tissue damage, immune complex IRFs P Type I IFN Innate receptor-mediated induction of type I IFN IRFs TBK1 TLR9 TLR7/8 TLR3 MyD88 TLR4 MyD88 TRIF IRAK Type I IFN Type I IFN Cytoplasm TRIF DAI dsDNA

Cytoplasm ISRE GAS Nucleus TYK2 JAK1 IL28R-a IL10R-b Type III IFN TYK2 JAK1 IFNAR1 IFNAR2 Type I IFN JAK1 JAK2 IFNGR2 IFNGR1 Type II IFN MX, 2,5-OAS, PKR IRFs CXCL10 RIG-I MHC SOCS others ISGs STAT1 STAT2 IRF9 P P P P P P ISGF3 Type II IFN Interferon signaling STAT1 STAT2 STAT1

Type I IFN function Type I IFN Antiviral Differentiation Apoptosis Source: All cell types, mostly by pDC Type I IFN Type I IFN Type I IFN Type I IFN Type I IFN pDC Proliferation Angiogenesis Antimicrobial Regulation of innate and adaptive immunity Type I IFN