Β Oxidation ↑Electron Donors Electron Transport Chain ↑FADH 2 ↑ O 2 - TCA Cycle ↑ FFA ↑ NADH+H + NAD + e-e- Complex I Complex III Complex II Complex IV Q-Q- e-e- e-e- e-e- FAD
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NITRIC OXIDE i Eight weeks of training in healthy adults Maeda, et al. Life Sciences 69: , 2001
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Harris, et al, Obesity, 2008 Active & Inactive Overweight Men Active & Inactive Overweight Men FMD Response Treadmill Exercise Treadmill Exercise
Oxidative Source Oxidative Stress ( 8 PG F2alpha) Endothelial Function Single Physical Activity Session NO bioavailability Blood Flow Anti- inflammatory Myokine ( IL-6) Inflammatory Stress ( TNF-alpha) Antioxidant Defense ( SOD) Insulin Resistance Visceral Fat ( TNF-alpha) Systemic Inflammation ( CRP) Habitual Physical Activity Insulin Resistance