Β Oxidation ↑Electron Donors Electron Transport Chain ↑FADH 2 ↑ O 2 - TCA Cycle ↑ FFA ↑ NADH+H + NAD + e-e- Complex I Complex III Complex II Complex.

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Presentation transcript:

Β Oxidation ↑Electron Donors Electron Transport Chain ↑FADH 2 ↑ O 2 - TCA Cycle ↑ FFA ↑ NADH+H + NAD + e-e- Complex I Complex III Complex II Complex IV Q-Q- e-e- e-e- e-e- FAD

Hamby et al, Diabetes Care 26: , 2003 Watts, et al, Journal Pediatrics 144: , 2004 Walsh, et al, JAP 95:20-25, 2003 Hamby et al, Diabetes Care 26: , 2003 Watts, et al, Journal Pediatrics 144: , 2004 Walsh, et al, JAP 95:20-25, 2003 EXERCISE IMPROVES ENDOTHELIAL FUNCTION

NITRIC OXIDE i Eight weeks of training in healthy adults Maeda, et al. Life Sciences 69: , 2001

Padilla, et al., European Journal of Applied Physiology, 98: , 2006

Padilla, et al. Medicine and Science in Sport and Exercise, in press.

Fly, et al. Medicine and Science in Sport and Exercise, in press.

Padilla, et al. Medicine and Science in Sport and Exercise, in press.

Harris, et al, Obesity, 2008 Active & Inactive Overweight Men Active & Inactive Overweight Men FMD Response Treadmill Exercise Treadmill Exercise

Oxidative Source  Oxidative Stress (  8 PG F2alpha)  Endothelial Function Single Physical Activity Session  NO bioavailability  Blood Flow Anti- inflammatory Myokine (  IL-6) Inflammatory Stress (  TNF-alpha) Antioxidant Defense (  SOD)  Insulin Resistance  Visceral Fat (  TNF-alpha)  Systemic Inflammation (  CRP) Habitual Physical Activity  Insulin Resistance