Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy.

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Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 22 Pharmacology of Hemostasis and Thrombosis Chapter 22 Pharmacology of Hemostasis and Thrombosis

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Sequence of Events in Hemostasis Figure 22-1

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Adhesion and Aggregation Figure 22-2

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Activation Figure 22-3

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Activation by Thromboxane A 2 Figure 22-4

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Platelet Activation by ADP and Thrombin Figure 22-5

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Coagulation Cascade Figure 22-6

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Coagulation Factor Activation on Phospholipid Surfaces Figure 22-7

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Central Role of Thrombin in the Coagulation Cascade Figure 22-8

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Antithrombin III Action Figure 22-9

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins The Fibrinolytic System Figure 22-10

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Virchow’s Triad Figure 22-11

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Overview of Prostaglandin Synthesis Figure 22-12

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Mechanism of Action of Antiplatelet Agents Figure 22-13

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Mechanism of Action of Warfarin Figure 22-14

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Differential Effects of Unfractionated Heparin, Low-Molecular- Weight Heparins, Selective Factor Xa Inhibitors, and Direct Thrombin Inhibitors on Coagulation Factor Inactivation Figure 22-15

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