Opportunities for future primary research

Existing research: ERNIE collaboration Combined database on childhood infectious disease Matthew Thompson et al. Opportunities for future research: CPRs for pneumonia and other serious infections Validation and/or development across Europe

Existing research: When should HIV patients return for CD4 testing? Individualized predictions of the safe interval between tests Individualized predictions of the safe interval between tests Rafael Perera, Thierry Buclin Rafael Perera, Thierry Buclin Opportunities for future research: Individualized re-testing dates for any chronic condition

Existing research: Vital signs in sick children Matthew Thompson / Engineering, Oxford Opportunities for future research: Validation studies Randomized trial with major outcomes

Existing research: Cardiovascular risk in diabetes Richard Stevens and Oxford Centre for Diabetes, Endocrinology & Metabolism Opportunities for future research: Usability, acceptability to GPs Risk communication to patients

Existing research: Horizon Scanning programme New diagnostic technologiesNew diagnostic technologies New usesNew uses New clinical prediction rulesNew clinical prediction rules Annette Plüddemann Annette Plüddemann Opportunities for future research: Integration with the International Register? First-in-field evaluation studies

Existing research: Systematic review of centiles for heart rate and breathing rate Susannah Fleming et al. Engineering, Oxford Opportunities for future research: Methodology for this kind of meta-analysis

Opportunities for primary research New prediction rules Validation studies Large RCTs with major outcomes e.g. readmission Small RCTs with surrogate outcomes e.g. clinician knowledge, patient education Methodological studies e.g. meta-analysis, validation methods, quantifying usability Qualitative studies with clinicians e.g. usability, acceptability Qualitative studies with patients e.g. risk communication, education