Transfer of LacZ Marker Gene to the Meniscus* by HIDEYUKI GOTO, FRANKLIN D. SHULER, CHANIN LAMSAM, HANS D. MOLLER, CHRISTOPHER NIYIBIZI, FREDDIE H. FU,

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Presentation transcript:

Transfer of LacZ Marker Gene to the Meniscus* by HIDEYUKI GOTO, FRANKLIN D. SHULER, CHANIN LAMSAM, HANS D. MOLLER, CHRISTOPHER NIYIBIZI, FREDDIE H. FU, PAUL D. ROBBINS, and CHRISTOPHER H. EVANS J Bone Joint Surg Am Volume 81(7): July 1, 1999 ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 1 Horizontal section of a human meniscus two weeks after an adenoviral vector containing the lacZ gene was injected directly into the meniscus in vitro (X-gal and eosin, x 200). HIDEYUKI GOTO et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 2 Horizontal section of a lapine meniscus three weeks after an adenoviral vector containing the lacZ gene was incorporated into a fibrin clot and then implanted into a meniscal tear (X-gal and eosin, x 200). HIDEYUKI GOTO et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Figs. 3-A through 3-E: Radial sections of canine menisci after retrovirally mediated ex vivo gene transfer to an operatively created defect (and control specimens) (X-gal and eosin). HIDEYUKI GOTO et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-B Four weeks after gene transfer, there were lacZ+ cells (stained blue) embedded in a dense fibrous tissue in the defect (x 400). HIDEYUKI GOTO et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-C Six weeks after gene transfer, there were lacZ+ cells (stained blue) in the defect (x 400). HIDEYUKI GOTO et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-D A control specimen in which collagen gel without cells had been implanted (x 200). HIDEYUKI GOTO et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-E A control specimen in which collagen gel without cells had been implanted (x 200). HIDEYUKI GOTO et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.