Responding to environmental signals Inter-cellular communication—driving cell division.

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Responding to environmental signals Inter-cellular communication—driving cell division

JUXTACRINE

Anchorage dependence

Contact-dependence

P HIPPO signaling pathway

Paracrine (local) signaling through receptor tyrosine kinases (RTKs)

How does GF binding lead to mitosis?

Phosphorylation Cycle

Activation of a MAP Kinase- Kinase-Kinase (MAP-KKK) Transcription of genes that promote cell division Activation of a MAP Kinase- Kinase (MAP-KK) P Activation of a MAP Kinase- Kinase (MAPK) P Activation of a transcription factor P

GAP GEF

Receptor overexpression (frequent collisions/dimerization) hypersensitive to low levels of GF GF-independent signaling Receptor point mutation or deletion (constitutive signaling) Fusion protein (constitutive signaling) Activation of messenger protein

Paracrine signaling through non-tyrosine-kinase receptors

I NHIBIT CELL DIVISION

Sonic, Indian, Desert differentiation

wnt activated frizzled division

Autocrine Signaling

Juxtacrine Signaling

Juxtacrine signaling to promote division

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