High Concentrations of AGE-LDL and Oxidized LDL in Circulating Immune Complexes Are Associated With Progression of Retinopathy in Type 1 Diabetes Featured.

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High Concentrations of AGE-LDL and Oxidized LDL in Circulating Immune Complexes Are Associated With Progression of Retinopathy in Type 1 Diabetes Featured Article: Maria F. Lopes-Virella, M.D., Ph.D., Nathaniel L. Baker, M.S., Kelly J. Hunt, Ph.D., Timothy J. Lyons, M.D., Alicia J. Jenkins, M.D., Gabriel Virella, M.D., Ph.D., The DCCT/EDIC Study Group* Diabetes Care Volume 35: June, 2012

Study Objectives Lopes-Virella M et al. Diabetes Care 2012;35: To determine whether immunocomplexes (ICs) containing advanced glycation end product –LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes

Study Design Lopes-Virella M et al. Diabetes Care 2012;35: participants in the DCCT/EDIC cohort Levels of AGE-LDL and oxLDL in ICs measured Retinopathy assessed by stereoscopic fundus photography Cox proportional hazards models used to assess effect of AGE-LDL-ICs and oxLDL-ICs on retinopathy progression

Lopes-Virella M et al. Diabetes Care 2012;35:

Conclusions Increased levels of AGE-LDL and oxLDL in ICs are associated with increased risk for progression to advanced retinopathy in patients with type 1 diabetes Suggests that the antibody response to modified LDL plays a significant role in retinopathy progression Lopes-Virella M et al. Diabetes Care 2012;35: