Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial Featured Article: Saila B. Koivusalo, Kristiina Rönö, Miira M. Klemetti, Risto P. Roine, Jaana Lindström, Maijaliisa Erkkola, Risto J. Kaaja, Maritta Pöyhönen- Alho, Aila Tiitinen, Emilia Huvinen, Sture Andersson, Hannele Laivuori, Anita Valkama, Jelena Meinilä, Hannu Kautiainen, Johan G. Eriksson, and Beata Stach-Lempinen Diabetes Care Volume 39: 24–30 January 2016

STUDY OBJECTIVE To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention Koivusalo S.B. et al. Diabetes Care 2016;39:24–30

STUDY DESIGN AND METHODS 293 women with a history of GDM and/or a prepregnancy BMI of ≥30 kg/m2 were enrolled in the study at <20 weeks of gestation Subjects were randomly allocated to the intervention group or the control group Subjects in the intervention group received individualized counseling on diet, physical activity, and weight control from trained study nurses and had one group meeting with a dietitian Control group received standard antenatal care Diagnosis of GDM was based on a 75-g, 2-h oral glucose tolerance test at 24–28 weeks of gestation Koivusalo S.B. et al. Diabetes Care 2016;39:24–30

RESULTS 269 women were included in the analyses Incidence of GDM was 13.9% in the intervention group and 21.6% in the control group Gestational weight gain was lower in the intervention group Women in the intervention group increased their leisure-time physical activity more and improved their dietary quality Koivusalo S.B. et al. Diabetes Care 2016;39:24–30

CONCLUSIONS A moderate individualized lifestyle intervention reduced the incidence of GDM by 39% in high-risk pregnant women Koivusalo S.B. et al. Diabetes Care 2016;39:24–30