National Alliance for Medical Image Computing Volumetric Studies

National Alliance for Medical Image Computing Current Technology Image Acquisition: –1.5 Tesla GE scanner, 1 coronal SPGR, 1 axial Double Echo PD and T2w image. Rigid Registration: –Mutual Information Alignment. Brain Segmentation: –Expectation Minimization Segmentation in 4 tissue classes (White, Gray, CSF and Face). Manual Segmentation of Regions Of Interests. Statistical Analysis of the ROIs’ Volume.

National Alliance for Medical Image Computing 3D Slicer Segmentation –Level set –Fast Marching –EM Registration –Rigid –Non Linear 3D modeling Filtering Visualisation …

National Alliance for Medical Image Computing Brain Segmentation W. Wells

National Alliance for Medical Image Computing Posterior Superior Temporal Gyrus (STG) Red = Left, Green= Right Amygdala. Yellow = Left, Light Blue = Right Hippocampus (Hipp.). Orange = Left, Dark Blue = Right Parahippocampal Gyrus (PHG). Dark Pink = Left, Purple = Right L. STG Hipp. L. Post. STG L. Ant. STG L. Hipp. L. Amygdala. PHG Hirayasu et al.

National Alliance for Medical Image Computing Volumetric Studies Findings Lateral Ventricles & CSF Enlargement. Parietal Volume Reduction. Temporal Lobe Volume Reductions –Amygdala-Hippocampal Complex, Parahippocampal Gyrus, & Superior Temporal Gyrus. Prefrontal Volume Reduction. Basal Ganglia (Caudate, Putamen, Globus Pallidus) increases and decreases.

National Alliance for Medical Image Computing Volumetric Studies

National Alliance for Medical Image Computing Shape: Global Measures J. Levitt and C.F. Westin

National Alliance for Medical Image Computing Shape: Surface Based Analysis H.J. Park and J. Levitt

National Alliance for Medical Image Computing Shape: Medial Representations J. Levitt and S. Bouix

National Alliance for Medical Image Computing Technical Challenges Image Quality and Acquisition Sequences. Multi Channel Atlas Based Segmentation. Multi Channel Image Registration. Model Based Segmentation. Shape Analysis. Cortical Thickness.