Olympic CFM 600 Cerebral Function Monitor Group 14

Members JP Day, BME Brian Snelling, BME Colin Compas, BME Dr. Paul King, Faculty Advisor Dr. Bill Walsh, Advisor Dr. John Wikswo, Collaborator Dr. A.B. Bonds, Collaborator

Device Description Cerebral Function Monitor –Continuously measures brain activity –Normal reading Between μV –Detects Oxygen loss (HIE) Drug side effects Seizures

Project Description –Electromagnetic Interference Abnormal readings –Due to other devices in room ECG –1000 greater in amplitude –Physically close to brain –Solution(s): Manual suggests moving devices –Based on output wattage –Some distances unrealistic Shielding –Devices in room –CFM

CFM Tracings Normal tracing characterized by central band in the 10-40µV range with a normal sleep wake cycle Abnormal tracing characterized by lower, narrow band of activity with spikes indicating burst suppression EMI can lead a normal signal to resemble the abnormal signal which can lead to misdiagnosis of a baby’s cognitive function.

Completed Work Met with Dr. Bill Walsh –Discussed problem –Solution parameters Background Reading –CFM Manuals –EM shielding literature –Journal articles Established Firm Timeline –Meet with advisors –Use gathered knowledge in NICU room Ruled out Moving Devices

Operator’s Manual Suggestions d=distance in meters

Shielding Techniques Faradays Box – This is a box that fits around the device and has one grounding wire EMI Mesh – Woven wire of different materials helping to block outside interference Jackets and Sheaths – Made out of Various Materials EMJ Foil Tape – Adhesive layered foil that can be crafted around most geometries

Current Work Scheduled Meetings: –Dr. AB Bonds –John Wikswo Explore shielding options Contact Olympic Medical –Waiting for return call Discuss nature & frequency of problem Possible solution NICU room –Map room –Get specs for devices –Contact nurse familiar with CFM

Future Work Develop EM shield –Based on: Professors’ suggestions Shielding literature Improve CMR of amplifiers Actively filter ECG signal Test posed solutions

References Vries L, Hellstrom-Westas L. Role of cerebral function monitoring in the newborn. Archives of Disease in Childhood, 2007;27. Spitzer A. Neonatal Cerebral Function Monitoring. Neonatalogy Today, 2006;1:1-12. Gluckman P, Wyatt J, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multi-centre randomized trial. Lancet. 2005;365: al Naqeeb N, Edwards AD, Cowan FM, Azzopardi D. Assessment of neonatal encephalopathy by amplitude integrated electroencephalography. Pediatrics 1999; 103(6):1263–1271. Archbald F, Verma UL, Tejani NA, Handwerker SM. Cerebral function monitor in the neonate. II: Birth asphyxia. Dev Med Child Neurol 1984; 26(2):162–168. Greisen G. Tape-recorded EEG and the cerebral function monitor: amplitude-integrated, time-compressed EEG. J Perinat Med 1994; 22(6):541–546. Thornberg E, Thiringer K. Normal pattern of the cerebral function monitor trace in term and preterm neonates. Acta Paediatr Scand 1990; 79(1):20–25. Verma UL, Archbald F, Tejani NA, Handwerker SM. Cerebral function monitor in the neonate. I: Normal patterns. Dev Med Child Neurol 1984; 26(2):154–161.