How the environment affects the brain Not only can the brain determine and change behaviour, but behaviour and environment can change the brain

Brain Plasticity Before 1960s, the brain was thought to be unchangeable After, the view has changed through many studies on humans and animals. Brain plasticity: the brain’s ability to change due to learning or experience

Brain Plasticity Environmental input can modify the brain, especially the cerebral cortex, which is the area of higher cognitive functioning The brain adapts to the New challenges High levels of stimulation and numerous learning opportunities at the appropriate times lead to an increase in the density of neural connections

Dendritic Branching The dendrites of the neurons grow in numbers and connect with other neurons, because… Every time we learn something new, the neurons connect to create a new trace in the brain. Example: if you spend a lot of time studying, compared to someone who doesn’t, you should have a thicker area in the cortex related to that knowledge. Example of someone who did not get a lot of stimulation: Genie

Effect 1: stimulation Physiological process: brain plasticity (your brain will change due to stimulation)

HUMANS as participants

The Romanian Orphans In 1989 Nicolae Ceauescu regime was overthrown in Romania. the world became aware of thousands of children who were warehoused in Romanian orphanages. watch?v=3ISSgupUtpUhttp:// watch?v=3ISSgupUtpU

between 100,000 and 300,000 children lived in these baby homes or orphanages Most children experienced severe emotional and physical deprivation. Many of the children was apathetic They could not walk, speak and used diapers, almost like they had mental disabilities. This showed that the lack of care made them “sick”. Case studies on the children

When Westerners saw television documentaries of the appalling conditions, many were eager to adopt and rushed to take action. thousands of adoptive parents from the United States, Canada and other countries ultimately succeeded in adopting children.

The simultaneous adoptions of so many Romanian orphans provided researchers with a unique opportunity to view the impact of adoption on primarily institutionalized babies and young children.

The outcomes of neglect According to Bruce Perry, institutionalized and neglected children tend to show low IQs, developmental delays and small head size. This developmental trend is reversed when children are placed in good foster homes or adopted, younger children making better progress than older ones. Perry’s investigation of head size leads him to conclude that neglect results in impaired brain development and he supports this conclusion by referring to evidence from brain scans. “Childhood Experience and the Expression of Genetic Potential: What Childhood Neglect Tells Us About Nature and Nurture”.Childhood Experience and the Expression of Genetic Potential: What Childhood Neglect Tells Us About Nature and Nurture

Neglect in early childhood Perry and Pollard 1997 examined various aspects of neurodevelopment in neglected children. Global neglect: a history of relative sensory deprivation in more than one domain (e.g. minimal exposure to language, touch and social interactions). Chaotic neglect: more common and with a history of consistent physical, emotional or cognitive neglect. History was obtained from multiple sources (e.g. investigating CPS (child protective service) workers, family and police)

Procedure The neglected children (n=122) were divided into four groups: 1.Global neglect (GN; n=40) 2.Global neglect with Prenatal Drug Exposure(GN+PND; n= 18) 3.Chaotic neglect (CN; n= 36) 4.Chaotic neglect with Prenatal Drug Exposure (CN+PND; n = 28)

Procedure Measures of growth were compared across group and compared to standard norms developed and used in all major pediatric setting. FOC (the frontal-occipital circumference) is a measure of head size

Results Globally neglected children had lower FOC values indicating abnormal brain growth. The group mean was below the 5 th percentile. Chaotically neglected children did not demonstrate this marked difference. In cases where MRI and CT scans were available, 11 out of 17 (64,7%) scans were abnormal in GN group compared to only 3 of 26 scans from the CN group (11,5%). Enlarged ventricles or cortical atrophy (see next slide)

Deprivation has a measurable effect on brain growth

Linking back to the effect: These findings strongly suggest that when early life neglect is characterized by decreased sensory input (e.g., relative poverty of words, touch and social interactions) it will have a similar effect on humans as it does in other mammalian species. Sensory deprivation has been demonstrated to alter the physical growth and organization of the brain in animals. The present studies suggest that the same is true for children globally neglected in the first three years of life.

It is important to emphasize the timing of the neglect. The brain is undergoing explosive growth in the first years of life, and, thereby, is relatively more vulnerable to lack of organizing experiences during these periods. These unfortunate globally neglected children (some literally were raised in cages in dark rooms for the first years of their lives) appear to have altered brain growth. There are likely many factors contributing to this observation. Nutrition is one key aspect. Based upon the relative impact on the brain as opposed to other growth, a total nutritional explanation is inadequate. It is likely that the actual lack of experiences (sound, smell, touch) associated with global neglect in these children plays a major role.

Evaluation?

Evaluation All we have is a correlation between neglect and poor development. We don’t know which elements of the neglect caused what developmental deficits. But the research has high ecological validity On humans and not on animals (supporting) Ethics: children

Impoverished environment Enriched environment Rosenzweig and Bennet (1972) The effect of stimulation on p. 46 Study on rats (animal experiments) Aim: animals raised in highly stimulating environments will demonstrate differences in the brain growth and chemistry when compared with animals reared in dull circumstance IV: Enriched (toys) and deprived environment (no toys)

Spent 30 or 60 days in their environment Then sacrificed: Post-mortem studies Results: one group had increased thickness in the cortex, frontal lobe (associated with thinking, planning, decision making) similar studies have shown that it will increase even more if they also had company (other rats)) Company + toys = the best condition for a developing cerebral cotex

Evaluation Can these findings be generalized to humans? What the strenghts and limitations?

Strengths: (of a lab experiment) Can be replicated easily The duration of the experiment Replicated studies had supporting results Limitations: (of a lab experiment) Ethics Can the Rats’ behaviours be generalised to humans?

For: The results could not be obtained by any other method. If humans were used in this study, long term psychological and physical harm could have occurred. The treatment of the rats, until they were sacrificed, was to an acceptable standard. Against: Unethical to sacrificed rats to obtain a result that may not even be applicable to humans. The rats in the deprived cage endured unfair treatment, lacked social contact and lived in small cages.

Videos The Plastic Brain (full animation) rcVMgbI rcVMgbI The Learning Brain s4 (can you spot the TOK link?) s4

Effect 3: (amount of light/darkness) physiological process: melatonin production and changes that could lead to SAD Melatonin production due to the environment (darker days – more production, could lead to SAD) You can use the same knowledge here as for the learning outcome for hormones (same study). But then you also need to evaluate the study: Method, gender, culture, ethics

Effect 4: Environmental stressors and hippocampal damage in PTSD patients PTSD: post traumatic stress disorder A stressor could be any event that threatens to disrupt the body’s normal balance Example: being attacked, having an accident, worrying too much (abuse, war, rape) The fight or flight response activates Cortisol is being released over a long period of time

PTSD War veterans and survivors of childhood sexual abuse are likely to suffer from PTSD Tend to have problems such as forgetfulness and difficulty of learning Physiological changes has been observed in such patients, especially in the hippocampus (important role in memory) due to cortisol

PTSD: Study Bremner et al studied stress, PTSD and memory problems related to reduction of hippocampal volume Aim: to measure the volume of the hippocampus based on the theory that prolonged stress may reduce the volume of the hippocampus due to increased cortisol levels

Bremner et al Procedure: participants (veterans and female adults who had experienced sexual abuse as young, some had PTSD, some did not) They completed memory tests while being put through MRI scans

Bremner et al Results: They found that the hippocampus was smaller in PTSD patients The veterans with most memory problems had the smallest hippocampus Clear correlation between number of years of abuse, memory problems and hippocampal volume Evaluation:?

Another study’s result: MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder by Bremner et al. 2003