Structure of a Cell (Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell, Lawrence.

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Presentation transcript:

Structure of a Cell (Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell, Lawrence Zipursky)

Concept of a Gene Mendelian genetics: A unit of inheritance that usually is directly responsible for one trait or character Moden molecular biology: Specific segments of DNA that control cell structure and function; the functional units of inheritance. Sequence of DNA bases usually code for a polypeptide sequence of amino acids.

Central Dogma in Molecular Biology

Replication

replication.MOV (An Introduction to Genetic Analysis by Anthony J. F. Griffiths, Jeffrey H. Miller, David T. Suzuki, Richard C. Lewontin, William M. Gelbart) replicatoin 2.MOV (Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell, Lawrence Zipursky)

Central Dogma in Molecular Biology

Gene Expression

Life time of an mRNA mRNA life cycle.MOV (Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell, Lawrence Zipursky)

Transcription transcription.MOV (Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell, Lawrence Zipursky)

Central Dogma in Molecular Biology

The Genetic Code

Why Triplets? ── 4 2 = 16 < 20 < 64 = 4 3

Translation translation.MOV (Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell, Lawrence Zipursky)

Central Dogma in Molecular Biology

References Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell, Lawrence Zipursky An Introduction to Genetic Analysis by Anthony J. F. Griffiths, Jeffrey H. Miller, David T. Suzuki, Richard C. Lewontin, William M. Gelbart Note: due to copyright issues, we ’ re unable to provide the animations online, but you can find them in the companion CDs of the above books, both of which are on reserve in Cabot Science library.