Lecture 22 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964.

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Lecture 22 Web: pollev.com/ucibio Text: To: Type in:

Hormonal regulation

The TCA

The brain problem… Most energy stored as fatty acids Brain only uses Glc Fatty acids  Glc? How does brain function during starvation?

Production of ketone bodies Starvation  Glycogen = 1 day Amino acids  Glc. BUT… Without TCA, liver makes “Ketone bodies” from fats

Ketone bodies

Diabetes & ketone bodies Extreme starvation  Muscle breakdown Brain has plenty of Glc!

If only…

Making fatty acids = adding 2 Cs to chain!

AcCoA  Malonyl CoA

ACP in FAS

FAS

Fatty acid synthesis

Substrate shuttling in FAS

Further steps…

Regulation of FAS & breakdown

Allosteric regulation of ACC

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