Ponpon’s Laboratory Room: D916 (Lab) ; D908 (Office) Department of Life Science, Tzu-Chi University 970 Hualien Taiwan EBV research group.

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Ponpon’s Laboratory Room: D916 (Lab) ; D908 (Office) Department of Life Science, Tzu-Chi University 970 Hualien Taiwan EBV research group

Epstein-Barr Virus (EBV) 1.Human gamaherpesvirus kb DNA, double strand, linear 3. EBV associated diseases Burkitt’s Lymphoma Hodgkin’s Disease Nasopharyngeal Carcinoma (NPC) Lymphoproliferative Disease EBV

Epithilium of oropharynx Persistent infection of B cells by EBV Downregulation of EBV gene Memory B cell infection Cytotoxic T cell GC B cell Naive B cell Cytotoxic T cell EBV infection No SHM

Orip Wp CpQp EBNALP EBNA2 EBNA3s EBNA1 AB C LMP2A/B LMP1 Latency I Latency II Latency III Wp using BL Latent infection mediated by EBV

EBNA2 EBNALP EBNA3A EBNA3B EBNA3C EBNA1 EBV episomes EBV efficiently converts human B lymphocyte into proliferating lymphoblasts Resting B cell LCL EBNA2 Binds to RBP-Jk Transactivates - EBNA Cp, LMP1 - c-Myc, CD21, CD23 LMP1 Recruits TRAFs Activates NF-kB, JNK Mimics CD40 signaling EBV LMP2A LMP1 LMP2B EBNA3s Regulators of EBNA2 function? EBNALP Co-activates with EBNA2

Young ladies lead our group 小尤 Miley Mo 伶芝雅琳冠吟

Members in Ponpon’s Lab. Research Assistant: Guan-Yin Liu Ling-Chih Chien Undergraduate: Yi-Liy Ming Yi-Ting Yu Ya-Ling Chen Gadd family BAG family p53 pKA and p21 EBNA1 PI: Pon 2 Hsp90 LMP1 vs Cp Gene therapy Fu-Yue Hsu: Graduate student: Ongoing project