Exam 1 Review: 50116Xm1Review.PPt First Hourly Exam 100 Pts Updated: February 15, Intro Clinical Epidemio DefClass Models

Intro501: Introduction to Cancer Biology and to the Course (501Intro.ppt)

Figure 1.11a The Biology of Cancer (© Garland Science 2007) Banding pattern of normal metaphase human chromosomes

Figure 1.11b The Biology of Cancer (© Garland Science 2007) Fluorescent in situ hybridization (FISH) of normal metaphase human chromosomes using chromosome specific DNA probes with different fluorescent dyes

Figure 1.11c The Biology of Cancer (© Garland Science 2007) Aneuploid karyotype of human breast cancer cell. Note “scrambling” of colors demonstrating chromosomal reciprocal translocations

Figure 1.11d The Biology of Cancer (© Garland Science 2007) Intra- chromosonal inversion by M-band fluorescent in situ hybridization( mFISH)

Figure 1.14a The Biology of Cancer (© Garland Science 2007) Cytoskeleton: Actin microfilaments Microtubules Intermediate filaments

Figure 1.14b The Biology of Cancer (© Garland Science 2007) Intermediate Filaments of epithelial cell (keratin) in green Plasma membrane in blue

Figure 1.14d The Biology of Cancer (© Garland Science 2007) 3T3 Mouse Fibroblast attached to fibronectin extra- cellular matrix by integrin receptors

Clinical Presentation of Cancers (Clinical.ppt)

Figure 16.1b The Biology of Cancer (© Garland Science 2007)

Figure 16.1a The Biology of Cancer (© Garland Science 2007)

Introduction of PSA (prostate specific antigen) test to screen for prostate cancer

Figure 16.45a The Biology of Cancer (© Garland Science 2007)

See Figure 11.1, Cancer incidence at various ages for men and women. p Weinberg. Note maximum incidence per 100,000 population at about age 70, then drop off after that age. Serious incidence begins around age 35 except for breast cancer which can have an earlier onset depending on genetics. Incidence of Various Kinds of Cancers in Men and Women as a Function of Age

Figure 16.45c The Biology of Cancer (© Garland Science 2007)

Figure 11.8b The Biology of Cancer (© Garland Science 2007)

Figure 14.50a The Biology of Cancer (© Garland Science 2007)

Figure 14.50b The Biology of Cancer (© Garland Science 2007)

Epidemiology of Cancers (Epidemio.ppt)

Figure 4.12 The Biology of Cancer (© Garland Science 2007) Incidence of Burkitt’s Lymphoma in Relation to Infectious Disease Etiology: Aedes simpsoni mosquito transmission vector for malaria and Epstein Barr Virus co-infection

Figure 2.20 The Biology of Cancer (© Garland Science 2007) Cancer Incidence Following Migration p. 45

CigBooze

Definitions of Classifications of Cancer (DefClass.ppt)

Normal Secretory & Ciliated Epithelial Cells Figure 16-19, ECB, 1998, p. 528 RespCilia Ciliated Epithelium of Human Respiratory Tract

Figure 11.7 The Biology of Cancer (© Garland Science 2007) Prpgression in Neoplastic Development: Weinberg, Chapter 11 on Multistep Tumorigenesis. Figure 11.7

Cancer Incidence 2002: 1,285,000. Cancer Deaths 555, % Death Rate Cancer Incidence 2009: 1,479,000. Cancer Deaths 562, % Death Rate

Table 2.3 The Biology of Cancer (© Garland Science 2007) p. 33

Hematopoiesis (formation of blood cells) Fig 2-1, Kuby 4th Ed. p. 28 HematoAll

Pluripotent Stem Cell and Lymphoid and Myeloid Lineages (Fig 2-1, Kuby 4th Ed. p. 28 Myeloid Stem Cell StemCell

Lymphoid Lineage Fig 2-1 Kuby 4th Ed p. 28

Myeloid Lineage (Kuby, Fig 2-1, 4th Ed., p. 28) Myeloid

Figure 8.32 The Biology of Cancer (© Garland Science 2007) Disease Progression in Chronic Myelogenous Leukemia p. 293

Model Systems in the Study of Cancers (Models.ppt)

What Models of Cancers Do We Actually Use in Cancer Biology and Cancer Medicine ? Neoplastic and Normal Cell Lines in Culture Transformed Normal Cells Freshly-derived Cancer Cells Genetically Engineered Cells Engineered Tissues (3-Dimensional Cell Cultures) Animal Models in Cancer Research and Cancer Medicine (“Pre-Clinical Trials”) Inbred Animal Models Veterinary Animals Animal-Human Engineered Hybrid Models Clinical Cancer in Patients Clinical Trials (Phase I, Phase II, and Phase III) Dr. Steve Graziano: Lung Cancer Therapy (Last week of class)

Figure 13.8 The Biology of Cancer (© Garland Science 2007) p. 539 Primary excised surgical tumor pieces Surgical specimens after 3 to 6 months growth sub-cutaneously in SCID Mice Prostate and colon cancer cell lines propagated in vitro and implanted Comparisons of Two Primary Cancers vs the Cancers Propagated as Model Systems Cancer Comparisons

Cancer Model Systems In Vitro (in Cell, Tissue, or Organ Culture) Normal Cells in Culture Transformed Cells Chemically Virally By Irradiation Neoplastic Cells from Animal Tumors Neoplastic Cells Cultured from Human Cancers CxVitro

Animal Tumor Models in Vivo Source of the Tumor Challenge Cells Implanted Cultured Neoplastic Cells Transplanted from Donor Animals Early vs Later Transplant Generations Induced in the Tumor-bearing Host Animals Spontaneous (by Genetic Selection) Chemical, Viral, Radiation Induction Excised fromVeterinaryAnimals AnimlCx1

Clinical Human Cancers as "Model" Systems Advantages: The Closest "Model" to the Ultimate Goals...The Best Model for Human Cancer Patient Feed-back and Cooperation Limitations Unmatched, genetically unique subjects Powerful ethical limitations Patient Independence and Failure to Comply Prior or Concomitant Treatment Video on Clinical Trials in Patients A note on Experimental Cancer Therapy and National Health-Care Policy – Keith Olbermann, MSNBC Countdown, February 9, 2010

Obesity in the United States and the Future of Disease Incidence, Including Cancer Obesity and Medical Costs, ABSNEWS, Feb. 16, 2011 ObesityABC16Feb11.doc americans-exercise-food-advice-tips-health

The Ugly Truth of Pediatric Cancer A Five-minute musical mosaic of childhood cancer Google the Title or Dec 19, Uploaded by KidsCancerChannel This video shows the ugly side of pediatric cancer, and just a glimpse into the... Ava's Cancer Storyby... More videos for The Ugly Story of Pediatric Cancer » Note: You may want to dispute the use of the word “Ugly” by those who compiled this montage of children with cancer. There is crushing sadness and heartache, but much of beauty shared by the children, their parents, and their brothers and sisters. TPF Feb. 9, 2013

Cancer Treatment | PBS NewsHour | Jan. 1, 2001 | PBS Jan 1, ELIZABETH BRACKETT: Last year, Kelley Mitchell lost her battle against cancer. But before the 16-year-old died, she agreed to try a highly... ne01/cancer_01-01.html Week Two: The Story of Kelley Mitchell and Ewings Sarcoma Last Presentation: The Story of Taylor Black and Neuroblastoma (“Daydreams and Diaries” - UntreedReads.com OnLine Story of Taylor Black by Tim Black)