Bio 328 Immunology The Complement System. Jules Bordet (1870-1961) Alexine Bordetella pertussis (whooping cough) 1916 Noble.

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Presentation transcript:

Bio 328 Immunology The Complement System

Jules Bordet ( ) Alexine Bordetella pertussis (whooping cough) 1916 Noble.

Spontaneous hydrolysis of C3 to C3(H 2 O) leads to fluid phase C3 convertase.

Bradykinin C3 and C5 C3a and C3b C5a and C5b Prekallikrein Kallikrein Kininogen Kallidin C3bB C3bBb Complement activation Active Hageman factor (XII) Plasmin

Plasminogen Activator inactive Plasminogen Activator active Kallikrein Thrombin Elastase Cathepsin Plasmin PlasminogenPlasmin C3 and C5 C3a and C3b C5a and C5b

Extracellular fibrinogen Binding Sbi CHIP Chemotactic Inhibitor Protein Staphylococcal kinase Protein A

The End