Carmen Nájera Department of Organic Chemistry University of Alicante Alicante (Spain) Cross-Coupling Reactions in Aqueous Media 1 2 nd International Conference on Past and Present Research Systems of Green Chemistry September 14-16, 2015 Orlando, USA 2 nd International Conference on Past and Present Research Systems of Green Chemistry September 14-16, 2015 Orlando, USA
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Challenge: very active catalyst ArCl activation ArOH activation C sp 3 activation C-H activation Catalysis in water Mild reaction conditions 6
High thermal, air and moisture stability Easy accessibility Unexpensive starting materials (ketones) Amenable to structural and electronic variations Features 7
8 Synthesis
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12 Allylic alcohols
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14 Arylations in H 2 O
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17 Aryl Chlorides + Arylboronic Acids
18 Aryl Chlorides + Alkylboronic Acids
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20 A. Corma et al., Chem. Commun. 2003, 606
21 Aryl Chlorides + Potassium Aryltrifluoroborates
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24 Allyl and Benzyl Chlorides + Arylboronic Acids
25 Allyl Chlorides + Potassium Aryltrifluoroborates
26 Benzyl Chlorides + Potassium Aryltrifluoroborates
27 Allyl and Benzyl Chlorides + Potassium Alkenyltrifluoroborates
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29 1-Naphthol derivatives studies
30 Aryl Imidazole-1-sulfonates: reaction conditions in water
31 Aryl Imidazole-1-sulfonates + Potassium trifluoroborates
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34 Aryl Imidazole-1-sulfonates: ligands study
35 Aryl Imidazole-1-sulfonates: scope
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37 Aryl Chlorides: surfactants study
38 Aryl Chlorides: scope
40 Synthesis of (E)--1,4-Enynes: ligand studies
41 Synthesis of (E)--1,4-Enynes: Pd source
42 Synthesis of (E)--1,4-Enynes: scope
44 Synthesis of 5-Carbapterocarpens
46 Synthesis of Pterocarpans and 5-Carbapterocarpans
48 Carbonylations in water
49 Synthesis of Amides and Nitriles
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52 Spanish Ministry of Science and Innovation: BQ , CTQ , Consolider INGENIO 2010 CSD , CTQ /BQU, CTQ Spanish Ministerio de Economia y Competitividad: CTQ P, CTQ REDC FEDER Generalitat Valenciana: PROMETEO/2009/039 and PROMETEOII/2014/017 University of Alicante CAPES (Brazil)
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54 Dimeric complexes Supported complexes