بسم الله الرحمن الرحيم. Accessory gland of Digestive system salivary gland liver pancreas gall bladder.

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Presentation transcript:

بسم الله الرحمن الرحيم

Accessory gland of Digestive system salivary gland liver pancreas gall bladder

liver largest organ and gland = 1.5 kg location: abdominal cavity beneath diaphragm

function -production of proteins (albumin, fibrinogen) -detoxification -production of bile (lipid digestion ) -accumulation & change of metabolite -double circulatory system: portal vein (70-80%) hepatic artery

structure: -Capsule (glisson's capsule) -trabeculae -lobe, lobule -hilum

1- hepatocyte: 2- sinusoids : Stroma: reticular connective tissue

Hepatocyte

Hepatocyte = polyhedral = 6 or more surface contact with: sinusoid wall contact with: with other hepatocyte

contact with other hepatocyte 1-tubular space canaliculi (first portin of bile duct system ) 2-fuse=2 plasma membrane tight junction gap junction

contact with sinusoid wall Disse space:Ito cell (fat storing cell) =stellate cell

Sinusoids: 1-Endothelial cell 2-kupffer cell(phagocytotic cell, product protein=5%)

Sinusoids:

The liver lobule 1-classic lobule 2-portal lobule 3-hepatic acinus (rappaport)

classic lobule -polygonal -centeral vein (center of lobule) -Hepatocyte( hepatic cord = radial) -Sinosoid= radial -Portal space= between different lobule

Portal space =Portal triad / space 1-Bile duct 2-hepatic arteriol 3-portal vein Nerve lymphatic vessel

Portal lobule center portal triad

hepatic acinus ( rappaport lobule ) diamond – shape Center of lobule = terminal branch of portal vein, -

double circulatory system 1-portal vein (70-80%) 2-hepatic artery hilum

portal vein

Bile ductal system --bile canaliculi -bile ductules (Hering canal) = simple cuboidal cell -bile duct

Bile canaliculi

در لحظات شادی ،خداوند را ستايش کن در لحظات سختی خداوند را جستجو کن در لحظات آرامش خداوند رامناجات کن در لحظات درد آور به خداوند اعتماد کن ودرتمام لحظات خداوند را شکر کن

Gall bladder

animation