Cytotoxic Effect of Zoledronic Acid-Loaded Bone Cement on Giant Cell Tumor, Multiple Myeloma, and Renal Cell Carcinoma Cell Lines by Pawel Zwolak, J. Carlos.

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Presentation transcript:

Cytotoxic Effect of Zoledronic Acid-Loaded Bone Cement on Giant Cell Tumor, Multiple Myeloma, and Renal Cell Carcinoma Cell Lines by Pawel Zwolak, J. Carlos Manivel, Piotr Jasinski, Mark N. Kirstein, Arkadiusz Z. Dudek, James Fisher, and Edward Y. Cheng J Bone Joint Surg Am Volume 92(1): January 1, 2010 ©2010 by The Journal of Bone and Joint Surgery, Inc.

Release of zoledronic acid from bone cement over time correlated to the amount of loaded drug in milligrams. Pawel Zwolak et al. J Bone Joint Surg Am 2010;92: ©2010 by The Journal of Bone and Joint Surgery, Inc.

Cytotoxic effect of eluted zoledronic acid on giant cell tumor cells as demonstrated by the MTT assay. Pawel Zwolak et al. J Bone Joint Surg Am 2010;92: ©2010 by The Journal of Bone and Joint Surgery, Inc.

Cytotoxic effect of eluted zoledronic acid on multiple myeloma cells as demonstrated by the MTT assay. Pawel Zwolak et al. J Bone Joint Surg Am 2010;92: ©2010 by The Journal of Bone and Joint Surgery, Inc.

Cytotoxic effect of eluted zoledronic acid on renal cell carcinoma (RBM1-IT4) cells as demonstrated by the MTT assay. Pawel Zwolak et al. J Bone Joint Surg Am 2010;92: ©2010 by The Journal of Bone and Joint Surgery, Inc.