Somatosensory System and Pain Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew.

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Presentation transcript:

Somatosensory System and Pain Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem lecture 4: Afferent input to the spinal cord 08-9 פיסיולוגיה מורחב 08-9 פיסיולוגיה מורחב

flexor reflex flexor reflex afferents nociceptors multisegmental response Collateral branching flexion  extension  nociceptive afferent

segmental reflex flexor reflex

primary sensory neurons

D V rostral caudal rostral cranial cervical thoracic lumbar sacral coccygeal caudal somatotopic mapping (note overlapping RFs)

substantia gelatinosa

Rexed laminae ventral horn dorsal horn A  Aδ C

SP NK1 substance P – neurotransmitter/ neuromodulator neurokinin 1 (NK1) SP receptor

somatotopic mapping Rexed’s laminae divergence convergence

dermatome L6 L4 L1 T10 T11 T10-T11 overlap dermatome somatotopic map

trigeminal system V1,V2,V3 V = 5 th cranial nerve opthalmic division maxillary division mandibular division caudal trigeminal nucleus = dorsal horn of V

proximal distal somatotopic map Med. Lat. rostral caudal fore hind proximo-distal rostro-caudal

succinyl dehydrogenase somatosensory mapping

somatotopic mapping Rexed’s laminae divergence convergence

BT+P+ P- WDR multireceptive some SG neurons are "nociceptive specific" X low threshold specific Rexed’s laminae

synaptic input into the dorsal horn

divergence

Divergence SA1

Convergence

divergence convergence

Somatosensory System and Pain Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem lecture 4: Afferent input to the spinal cord פיסיולוגיה מורחב

myotactic (stretch) reflex …demo simple behavior Polysynaptic antagonist muscle (inhibitory interneuron) Monosynaptic agonist muscle Muscle spindle כישור שריר Muscle spindle afferent (DRG)