A UNIQUE IN VIVO ASSAY FOR YOUR ONCOLOGY DRUG CANDIDATES Target Validation Efficacy and Toxicity Evaluation Arnaud Peyronnier Business Development Manager +33 (0) BioTrinity 2016 – Company Showcase – Tuesday 26 April 2016

2 Fast Sensitive Reliable Affordable 2 OUR MISSION: Radically increased productivity in drug discovery INOVOTION has developed a unique technology dedicated to early in vivo EFFICACY and TOXICITY evaluation of anti-cancer drugs. We propose FAST, SENSITIVE, RELIABLE and AFFORDABLE in vivo assays to evaluate anti-cancer molecules. Most drug discovery costs are for low value molecules, in preclinical tests. The lead validation/optimization and preclinical phases are the most expensive and the less productive. INOVOTION allows chemists and biologists to: - significantly improve the productivity of their drug discovery efforts - decrease risk in the preclinical phases - help make Go/No Go decisions

3 Fast Sensitive Reliable Affordable 3 INOVOTION: Early elimination of low value molecules Nb molecules in vitro preclinical A new step to eliminate low value molecules Decrease the risk in pre-clinical phases Rapid Go/No Go decisions Efficacy and Toxicity Evaluation An early and informative evaluation of your molecules

4 Fast Sensitive Reliable Affordable 4 Analysis TumorNodules OUR TECHNOLOGY Human Tumor Cell Grafts Treatment Period Tumoral Development Embryo Development days Tumor Upper CAM Lower CAM Vessels Target Validation Efficacy and Toxicity Evaluation

5 Fast Sensitive Reliable Affordable 5 Classical preclinical models INOVOTIONAvantages 2-3 months1 month Fast results just one month for your study 1,000 units of drug1 unit of drug High sensitivity requires minute amounts of your compounds test points test points Strong reliability high statistical significance - low p value Yes In vivo assays but no animal testing Affordable costs less than comparable techniques Other advantages: Early stage evaluation, to eliminate low value molecules before the mouse studies Great predictivity with the same human cancer cell lines as your other preclinical models MULTIPLE BENEFITS

6 Fast Sensitive Reliable Affordable 6 Compound types Small Molecules Peptides Antibodies Proteins Natural compounds Viruses Nanostructures Treatments types Compound by itself Synergetic effects Sequential effects Cell lines Standard cell lines (ATCC) Wild type or genetically modified Patient cells Cell lines panel INOVOTION ASSAYS: Large range of possibilities

7 Fast Sensitive Reliable Affordable 7 Colon Adenocarcinoma Rhabdomyosarcoma Melanoma Glioma OUR STANDARD OFFERS Efficacy and Toxicity Evaluation 4 experimental groups: Vehicle Reference compound Test compound dose 1 Test compound dose 2 Target Validation 4 experimental groups: Wild type cell line Modified cell line 1 Modified cell line 2 Modified cell line 3 YOUR RESULTS IN JUST 1 MONTH Human Tumors Cervix Adenocarcinoma Breast Adenocarcinoma Lung Carcinoma Pancreas Carcinoma Prostatic Adenocarcinoma Hepatocellular Carcinoma Adrenal Gland Carcinoma Kidney Adenocarcinoma

8 Fast Sensitive Reliable Affordable 8 INOVOTION's technology was created in 2009 by Prof. Jean Viallet (founder). Our technology is the result of 5 years of R&D and more than 180 studies involving academic labs and biotech pharmaceutical companies. We are a spin-off created in 2014, emanating from the IAB Cancer Center, Grenoble Alpes University (France). Our independent labs are located in Biopolis on the Grenoble Medical Campus. ABOUT US Customer Publications: MikaelianI, et al. Cancer Research KroissA, et al. Oncogene Al DhaheriY, et al. PLoSOne Prudent R, et al. Br J Pharmacol El Hasasna H, et al. Sci Rep

9 Fast Sensitive Reliable Affordable 9 OUR REFERENCES: More than 180 studies ECDYSIS PHARMA

10 Fast Sensitive Reliable Affordable 10 Test your compound on 10 cancers! Don’t miss any valuable molecules SPECIAL OFFER: April 15 th to June 15 th Lung Breast Cervix Liver Colon ProstateGlioma Melanoma Adrenal gland Kidney Pancreas Rhabdomyosarcoma 30% discount Multi-Cancer Screening

11 Fast Sensitive Reliable Affordable 11 CONTACT US: Save on your R&D Time! Our LabsINOVOTION Biopolis - 5 Av. du Grand Sablon 38700, La Tronche France Customer Contact Arnaud Peyronnier (direct) (cell) Follow us on Target Validation Efficacy and Toxicity Evaluation Multi-Cancer Screening 30% discount