(Haemaphysalis longicornis) SFTS Quasi-Product Certificated by KFDA DEPENS BUGS DOUBLE Product Information Tick Repellent (Haemaphysalis longicornis) SFTS (Prevention of Severe Fever with Thrombocytopenia Syndrome)

About Icaridin…. DOUBLE Common Name Chemical Name CAS No. Usage Icaridin, Picaridine, KBR3023 Chemical Name hydroxyethyl isobutyl piperidine carboxylate CAS No. 119515-38-7 Usage Broad Spectrum Insect Repellent Property None color, odor (Purity : over 97%) History Icaridin has been reported to be as effective as DEET without the irritation associated with DEET. According to the WHO, icaridin “demonstrates excellent repellent properties comparable to, and often superior to, those of the standard DEET.” In the United States, the Centers for Disease Control and Prevention recommends using repellents based on icaridin, DEET, or oil of lemon eucalyptus for effective protection against mosquitoes that carry the West Nile virus, Eastern Equine Encephalitis and other illnesses. Unlike DEET, icaridin does not dissolve plastics. Picaridin, first used in Europe in 2001, has been reported to be effective by Consumer Reports (7% solution) and the Australian Army (20% solution). Consumer Reports retests in 2006 gave as result that a 7% solution of picaridin offered little or no protection against Aedes mosquitoes (vector of dengue fever) and a protection time of about 2.5 hours against Culex (vector of West Nile virus), while a 15% solution was good for about one hour against Aedes and 4.8 hours against Culex. Natrapel 8 hour is a 20% based picaridin repellent that claims to be effective for 8 hours. Generally, Icaridin works very well with all the insects that are trying to find you so that they can bite you and feed off you - mosquitoes, midges, sand flies, biting flies and fleas, etc. It is said to be more effective against midges than DEET and it is also effective against ticks, chiggers and leeches, although it needs to be reapplied more frequently than it does for flying insects to remain effective.

About Ticks(Haemaphysalis longicornis ….) DOUBLE About Ticks(Haemaphysalis longicornis ….) Haemaphysalis longicornis is a species of tick. Lyme spirochetes and spotted fever group rickettsiae have been detected in H. longicornis, as have Ehrlichia chaffeensis and Anaplsma bovis, and SFTS (Severe Fever with Thrombocytopenia Syndrome) has also been shown to be transmitted via Haemaphysalis longicornis. SFTS (Severe Fever with Thrombocytopenia Syndrome) is decease generated by SFTS virus infected tick biting. SFTS virus is a phlebovirus in the family Bunyaviridae. SFTS is an emerging infectious disease recently described in northeast and central China. This virus has been found in the Chinese provinces of Anhui, Henan, Hubei, Jiangsu, Liaoning, and Shandong. SFTS occurs in rural areas, from March to November, and a majority of cases are found from April to July. The virus has caused deaths in China, Korea and Japan. SFTS has a fatality rate of 12% and as high as 40% in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia (low platelet count), leukopenia (low white blood cell count) and elevated liver enzyme levels. TICKS (Haemaphysalis longicornis) 1. Symptom Symptoms include fever, vomiting, diarrhea headache, multiple organ failure, thrombocytopenia, leukopenia, elevated liver enzyme levels. Ticks bites on human skin

About Ticks(Haemaphysalis longicornis ….) DOUBLE About Ticks(Haemaphysalis longicornis ….) 2. Vaccine There are currently no preventative vaccines available in the world. Delayed detection and treatment of disease, children or the elderly and frequently death. The only best way is prevention. 3. Occurrence in Korea

Change of Consumer’s Trend… DOUBLE Change of Consumer’s Trend… Adverse Effect DEET, Permethrin Regulation Loss of Purchasing Power Natural Repellent Lavender oil, Eucalyptus oil Low Efficacy Discomfort (Odor, Staning) Safe and Effective ICARIDIN Recommendation of WHO, USA CDC, ECDC etc. Strong Effective Safe (No adverse effect) Comfort

Change of Consumer’s Trend… DOUBLE Change of Consumer’s Trend… 1. DEET (Diethyltoluamide) The best widely used compound BUT Unpleasant odor, skin stimulator, affecter to central nerve system - above 200 million peoples use it worldwide, and more than 38% ones among USA populations still use annually a repellent product containing DEET - there are a variety of products such as liquid, lotion, cream, gel, and aerosol goods containing 5~100% of DEET (more than 230 products have been registered to US EPA) - the higher DEET concentration shows better repellency. In laboratory test, 50% of DEET showed repellent durance for 4 hours US EPA “DEET may cause partly eruption, swelling, itching, and eye stimulation “Especially because products containing high concentration of DEET have an side effect to children, EPA prohibits that a product containing DEET express a word or phrase such as safety to children Journal of The American Mosquito Control Association (1998) “DEET may cause central nervous system depression, urticaria, contact dermatitis,potential encephalopathic toxicity and rarely, death Damage to cetain plastics and synthetic rubber -“Causing material of Gulf War syndrome due to brain injury” 2. Permethrin - NIEHS, MHLW : Endocrine Disruptors (Eds) - WWF, EPA : environmental hormone - EU : TOXIC

Who recommends Icaridin… DOUBLE Characteristic of Products Who recommends Icaridin… WHO ; World Health Organization USA CDC ; Center for Disease Control and Prevention ECDC ; European Centre for Disease Prevention and Control Australia ; Queensland Government Queensland Health Germany ; Consumer Organization “Stiftung Warentest” Switzerland ;Swiss Tropical Institute Scottland ; Advanced Pest Solutions at the Univ. of Edinburgh’s Biospace Incubator facility

Characteristic of Products DOUBLE Characteristic of Products Qusai Product Certificated by KFDA Qusai-Product Certificated by Ministry of Food and Drug Safety Usage : Ticks (Haemaphysalis longicornis) Repellent Excellent Repellency and Long Lasting Time (Spray 3 ~4 times, Repel 4 hours) Low penetration potential (DEET absorbed into the skin maximum 70%) Safe for sensitive skin, there is no limit to age, use NO DEET !! NO PERMETHRIN !! NO DEET PERMETHRIN No DEET, No Permethrin contained No Adverse Effects on Human Health and the Environment No allergy

Characteristic of Products DOUBLE Characteristic of Products Seasons Using From March to November Use Indoor and Outdoor at the Same Time From kids to Senior Easy to Use No Sticky, No Unpleasant Odor, No Staining on Fabric No affect to the Frames, such as plastic products (DEET have to effect to plastic) Camping, Climbing, Fishing, Picnic, Soldier, Farmer, Sport, etc.

Summary of Product DOUBLE Type Pump Spray Function : Ticks (Haemaphysalis longicornis) Repellent A.I. Icaridin 15% Certification Qusai-Product, Ministry of Food and Drug Safety Usage Spray 3~4 times on the easy ticks infested textiles, shoes, bags, and mats, etc. Volume 60ml Package 72ea / ct Expiration Date 3 years after manufacturing date Remark Public Procurement Product