IN THE FOOTSTEPS OF ROBERT BOYLE. New Ways Of Organising Drug Discovery By Dr. Bernard Leddy PhD MPSI

Robert Boyle ( ) Father of Modern Chemistry

Lismore Castle

Lismore County Waterford

Boyle’s Air Pump

Reality Of Job Losses 7300 Jobs Lost Worldwide 2400 Jobs Lost U.K Jobs Lost U.S.A. 300 Jobs Lost Ireland.

Dr. John Dixon ‘’ A Business Model for UK Drug Discovery’’..’  ’Contractions raise Worldwide concerns since expectations for new medicines exists everywhere. They must be innovative, affordable and usually suitable for oral delivery. In general only small molecules provide this on a Worldwide basis’’.  ‘’ widespread Medicinal Chemistry outsourcing brings similar threats’’

Professor Joel Lexchin from York University, Toronto, Canada  The real innovation crisis is that Pharmaceutical Research and development turns out mostly minor variations on existing drugs‘’  more money is spent on promotion (25%) than on discovering new drugs (1.3%).  the remuneration of drug companies for their R&D should move to a model where companies increase their revenue by producing products that provide meaningful gains in health outcomes

Consider This… “GlaxoSmithKline is to pay $3bn in fines, in what is the largest healthcare fraud settlement in US history.” July “GlaxoSmithKline to buy Maryland- based company for $3 billion” July 2012.

What a Network Should Look Like.

What The Patent Cliff Looks Like

New Uses For Old Drugs Thalidomide

S isomer Teratogen

Professor Dakshanamurthy  developed a rational system for analysing the molecular structure of old, already licensed, drugs for potential new uses.  His system called Train Match Fit Streamline or TMFS for short  examine 11 parameters of drug structure in a way which characterises potential pharmacological activity.

Conclusion  We must now try and look at the World,as Boyle had to in the 17th. Century, from a completely new perspective.  We need to work together with a common purpose using the resources of the  Big Pharma companies,  the well endowed research foundations,  ancient Universities and new,  big research departments and small  linked through a network of mutual support and co- operation to ensure the future development of novel Pharmaceuticals.