A potent metabolic agent, regulator of biochemical hair-loss processes Stimucap A potent metabolic agent, regulator of biochemical hair-loss processes

THE HAIR LOSS Not only “thanks” to the 5 -reductase enzyme STIMUCAP Not only “thanks” to the 5 -reductase enzyme but also due to: Fibrosis & inflammation of connective tissues Involution of hair follicle Smaller and thiner hairs

HOW TO SOLVE THESE PROBLEMS? Looking for a multiple functional compound that is able to : Avoid these situations Promote a more healthy status to the follicle STIMUCAP

KALICHEM’S IDEA STIMUCAP Sodium DNA CLA Glutathione Stimucap

STIMUCAP Cla - Glutahione

CLA – Conjugated linoleic acid Essential fatty acid STIMUCAP Precursor to anti-inflammatory substances Regulator of nutrients’ transport (Component of the bio-membrane) Able to become a dermal component, crossing the derma

GLUTATHIONE Essential fatty acid STIMUCAP Powerful antioxidant Neutralizes free radicals that interfere with lipidic, proteic, enzimatic and DNA metabolism Essential for the production of anti-inflammatory compounds by CLA Essential in the elimination of toxic by-products of the metabolism

Sodium Dna STIMUCAP

SODIUM DNA Essential for: metabolism Cell repairing STIMUCAP Essential for: metabolism Cell repairing Tissue regeneration processes

Stimucap Sodium DNA STIMUCAP CLA Glutathione ANTINFLAMMATORY + ANTIOXIDANT REGERATIVE POWER Stimucap

A PICTURE… STIMUCAP Colourless Slightly viscous Hydro-soluble

In Vivo Evaluation

Vs PRODUCTS STIMUCAP LOTION CONTROL LOTION AQUA, ALCOHOL DENAT, POTASSIUM CLA GLUTATHIONE PEG-40 HYDROGENATED CASTOR OIL, PPG-26-BUTETH-26, PARFUM, SODIUM DNA STIMUCAP LOTION Stimucap@3% Vs AQUA, ALCOHOL DENAT, MINOXIDIL, PEG-40 HYDROGENATED CASTOR OIL, PPG-26-BUTETH-26, PARFUM CONTROL LOTION Minoxidil@2%

30 volunteers (age between 29 and 55 years) THE METHOD STIMUCAP 30 volunteers (age between 29 and 55 years) Volunteers affected by ALOPECIA & TELOGEN EFFLUVIUM 15 volunteers treated with Stimucap 15 volunteers treated with Minoxidil Once/day for 3 months (controls @ 1,2 and 3 months)

Dermatological evaluation of the scalp Global tolerability TESTS STIMUCAP Pull Wash Dermatological evaluation of the scalp Global tolerability Subjective evaluation

1 - PULL TEST  HAIR RESISTANCE STIMUCAP Holding hair tuft exercising constant traction. Count total number of hairs removed. 4 point scale: SCORE HAIR n° REMOVED IN 3 AREAS > 6 1 6 - 4 2 3 – 1 3

1 - PULL TEST  HAIR RESISTANCE STIMUCAP STIMUCAP MINOXIDIL HAIR RESISTANCE MONTHS

under controlled standard 2 - WASH TEST  HAIR LOSS STIMUCAP Fallen hair counted after washing under controlled standard conditions

2 - WASH TEST  HAIR LOSS STIMUCAP MINOXIDIL # HAIR LOST MONTHS

2 – DERMATOLOGICAL EVALUATION OF THE SCALP STIMUCAP Assessment of product’s global tolerability Objective evaluation 4 point scale: SCORE EVALUATION ABSENT 1 MODERATE 2 MILD 3 SEVERE

3 – DERMATOLOGICAL EVALUATION OF THE SCALP STIMUCAP STIMUCAP MINOXIDIL NO adverse local reactions on the skin BUT Minoxidil has to be taken under medical control

Assessment of global tolerability STIMUCAP Assessment of global tolerability Objective evaluation 5 point scale: SCORE EVALUATION POOR 1 MODERATE 2 MEDIUM 3 GOOD 4 VERY GOOD

Minoxidil has to be taken under medical control 4 – GLOBAL TOLERABILITY STIMUCAP STIMUCAP MINOXIDIL GOOD global tolerability BUT Minoxidil has to be taken under medical control

5 – SUBJECTIVE EVALUATION  PLEASANTNESS STIMUCAP PERCEPTION of efficacy & pleasantness 6 point scale : SCORE EVALUATION 1,0 BAD 1,2 .. 1,4 1,6 1,8 2,0 VERY GOOD

5 – SUBJECTIVE EVALUATION  PLEASANTNESS STIMUCAP STIMUCAP MINOXIDIL PLEASANTLESS MONTHS

BETTER hair resistance LESS hair loss WELL TOLERATED product CONCLUSION STIMUCAP BETTER hair resistance LESS hair loss WELL TOLERATED product NO side effects NO scalp irritation EFFICIENT COADJUTANT FOR TOPICAL TREATMENTS IN THE PREVENTION OF HAIR LOSS STIMUCAP

STIMUCAP Thank you Via Pastore 1 - 25082 Botticino Sera (Brescia) Italy Tel. +39 0302693532 - Fax. +39 0302193581 www.kalichem.it kalichem@kalichem.it