Life Sciences in Scotland An Opportunity

Life Sciences Industry – Overview Scottish Life Sciences Industry – Vision and Strategy Scottish Enterprise – Strategy Response and Role Scottish Life Sciences - Key Strengths and Projects Scottish Life Sciences – Connected and Working Together

Global Trends –the emergence of personalised medicine –the growing trend towards partnering, outsourcing and corporate venturing –move towards translational medicine and the use of biomarkers and associated diagnostics to improve the efficiency of the drug discovery process –focus on diagnostics –increasing convergence, with further integration between drugs and devices –increasing use of IT to accelerate discovery and drive down costs –increasing emphasis on search for alternative therapies for existing approved drugs.

Life Sciences Scotland - Key Facts Global top emerging 5 life science location 1 Second Largest Cluster 1 in the UK Home to 15% of UK life science companies 625 organisations 2, employing ~31,000 2 Turnover of £3bn 3 GVA of £1.39bn 3 Key strengths: Clinical/Translational Medicine Stem cells/regenerative medicine Medical Technologies Diagnostics Emerging Animal healthcare/vet medicine Healthcare Informatics (Bioinformatics, Imaging etc) 1 Fierce Biotech Scottish Enterprise, Jan ONS 2006 figures

Key Facts

Life Sciences Industry – Overview Scottish Life Sciences Industry – Vision and Strategy Scottish Enterprise – Strategy Response and Role Scottish Life Sciences - Key Strengths and Projects Scottish Life Sciences – Connected and Working Together

Current state 2009 Centres of Excellence Scotland is characterised by partially connected centres of excellence and world leading research. The majority of the company base (over 400) have under 50 employees.

Current state Centres of Excellence 2020 Vision Connected, integrated, coordinated Capital Translational medicine People Regenerative Medicine Scotland is characterised by partially connected centres of excellence and world leading research. The majority of the company base (over 400) have under 50 employees. A globally oriented, sustainable, fully connected life sciences sector built on collaborative action that exploits strengths in scientific excellence, financial services and innovative business models and develops, retains and builds upon Scotland’s talents.

Current state Centres of Excellence 2020 Vision Connected, integrated, coordinated Key Focus Areas People Technology Capital Infrastructure Collaboration Capital Translational medicine People Regenerative Medicine Scotland is characterised by partially connected centres of excellence and world leading research. The majority of the company base (over 400) have under 50 employees. A globally oriented, sustainable, fully connected life sciences sector built on collaborative action that exploits strengths in scientific excellence, financial services and innovative business models and develops, retains and builds upon Scotland’s talents.

Life Sciences Industry – Overview Scottish Life Sciences Industry – Vision and Strategy Scottish Enterprise – Strategy Response and Role Scottish Life Sciences - Key Strengths and Projects Scottish Life Sciences – Connected and Working Together

Supporting the Life Sciences Strategy - Principle SE response:  Growth of a sustainable company base  Delivering connected, world-class transformational projects SE Response

IDS - Principle SE response: Retain, Build and Attract World-Class Businesses of Scale  Anchor and grow key companies Pharma and Biotech Large Medtech Large CROs and Specialists suppliers  Increase inward investment Link to key areas of strength Strategic relationships Stimulate & Attract new SMEs and Support current SMEs  Smart working with Universities NHS Company base Areas of focus SE Response

Assistance for Account Management General Business Support –Intervention framework –Global Scots –Scottish Manufacturing Advisory Service Sector Specific Support –Segmentation criteria –Life Science Sector support –Life Science Business Advisory Service –ITI interaction moving forward

Supporting the Life Sciences Strategy - Principle SE response:  Growth of a sustainable company base –Retain, Build and Attract World-Class Businesses of Scale  Anchor, attract and grow key companies  Increase inward investment –Stimulate & Attract new high growth SMEs and Support current SMEs  Delivering connected, world-class transformational projects "Scotland is a fantastic place to build a medical diagnostic company. There's a lot of companies and there's quite a lot of expertise." Fiona Lowrie, CEO Forth Photonics, raised £6m 29 th Jan 09 SE Response

1. Developing, Attracting and Retaining Key Skills & Talented people (People) e.g. Talent Scotland, SDI. 2. Supporting economically driven commercialisation of research excellence and intellectual property (Technology) e.g. Proof of Concept, ITI. 3. Accessing Specialised Finance/Investment (Capital) e.g. Co Investment Fund. 4. Facilitating the provision of World-class Physical Infrastructure (Infrastructure) e.g. Alexandria Real Estate/BioQuarter. 5. Developing further effective collaboration and optimising networks and global activity (Collaboration) e.g. TMRC, Global Scot. SE’s contribution to Industry Driven Strategy Investment prioritisation SE’s contribution to Industry Driven Strategy Investment prioritisation SE’s role: Catalyst for change Facilitator Shared Risk and Investment Networks – National and International Driving industry leadership and innovation …and transformational programmes….

Key Focus stem cells and regenerative medicine translational and clinical medicine contract research diagnostics and medical devices

Major academic strengths Europe’s largest and most highly-regarded stem cell research community Scottish Centre for Regenerative Medicine (SCRM - £60m investment) & lead contractor for a £9million project to create a European consortium for stem cell research. Significant clinical development activity SNBTS (Scottish National Blood Transfusion Service); Medical Research Council and Cancer Research UK Centre, Western General Hospital Roslin Institute/Orthopaedics group at Royal Infirmary of Edinburgh (using stem cells to develop bone implants). University of Edinburgh/NHS Lothian : corneal epithelial stem cell transplantation, pancreatic islet cell transplantation Key life science strengths in Scotland – a Leading Centre for Stem Cell R&D

Commercial activity Geron : US based, strong links with Scotland Roslin Cells Ltd Stem Cell Services (spin-out from Scottish Biomedical) Cellartis AB Manufacturing/scale-up development £9m ITI Life Sciences programme for drug screening tools Angel Biotechnology Ltd Invitrogen : US-based, significant activity in Scotland Roslin Cells Ltd. Support/infrastructure Scottish Stem Cell Network, Stem Cell Translational Development Fund (£5m), Scottish Centre for Regenerative Medicine (£60m) Key life sciences strengths in Scotland – a Leading Centre for Stem Cell R&D

Transformational projects – Stem Cells

Why Scotland? World-class, internationally renowned research base in science and medicine Stable population with high rates of morbidity and chronic disease & willingness to contribute to clinical research Proven, effective collaboration ethos Centralised health care system with unique patient identifier Clinical support infrastructure Computerised data sets of national statistics Integrated approach to imaging (SINAPSE) Key Strengths: Translational Medicine

CRO (Pharmaceutical Support Network) Established network of 40+ pharmaceutical clinical trials support & contract research organisations including: Aptuit Charles River Laboratories CXR Biosciences Invitrogen PPD Scottish Biomedical Quintiles Scotland Ltd Key Strengths: CROs

Transformational Projects – Clinical/Translational Medicine

World-class wealth of resources, expertise and facilities ideally placed for med-tech design, manufacture & commercialisation Vibrant company base (150+) Aircraft Medical, Optos, Omega Diagnostics, LifeScan Scotland, J&J Medical, Bausch & Lomb, Toshiba Medical Scotland’s 13 universities involved in ground-breaking med-tech research Medical Device Doctoral Training Centre and Institute for Medical Devices situated at the University of Strathclyde Depth of experience in related and convergent technologies micro, opto electronics, imaging, biochemistry, nanotechnology Substantial clinical research and trials capabilities E.g. Charles River Laboratories, Pleiad Devices, PPD and NHSScotland Key Strengths: Medical Technology & Diagnostics

Transformational Projects – Edinburgh BioQuarter Science World top-20 Biomedical University Cardiovascular, Stem cells, animal health Talent Academic talent Multiple world- ranked research centres Internationally- recognised science leaders Commercial talent Internationally- experienced business leaders Powerful networks Scottish Stem Cell Network Bioinformatics Forum Life Sciences Alliance Capital Scottish Venture Fund Proof of Concept Fund Dedicated VC resource Scottish Seed Fund Location Comprehensive infrastructure for translational medicine BioQuarter – unique in UK Alexandria – global leader in life science clusters BioCampus – national manufacturing centre Complementary regulatory environment World top-5 Informatics Centre Intermediary Technology Institute

Summary Scotland’s competitive advantage High level and strong government commitment to sector Attraction of key companies Highly skilled workforce Strong academic and clinical base Academic/NHS close working – key for industry interaction World-class expertise in specialist technology, clinical and therapeutic areas Good connectivity and integrated working across sub-sectors Close working between organisations (private and public sector) towards common goals