Reproof, Rebrand, Revalue

Executive Summary N4 Pharma - a UK-based pharma reformulation company with strong patents and proprietary technology which it uses to revitalise and revalue existing drugs lead product is an improved version of Sildenafil (Viagra); faster onset of action with effective level of drug maintained in its therapeutic window from dose to dose. Exclusive global rights to two proprietary vaccine delivery platforms for sub unit vaccines, messenger RNA and plasmid DNA molecules. N4 maintains strong intellectual property portfolio and is funded by AIM listed investment company Onzima Ventures Plc Setting up Special investment vehicles for its reformulated Viagra, vaccines and other new product reformulation opportunities –Each opportunity with blockbuster potential 2

Strong Intellectual property 3 N4 has 4 platform technologies allowing reformulation and improvement of a wide range of existing drugs OPAL IPCocrysNuvacNuvec Wide range of patents drafted by ex GSK head of patents Patent from Bradford University to manufacture cocrystals using Hot Melt extrusion Silica nano particles designed to improve sub unit vaccines Silica nano particle delivery platform for mRNA and pDNA molecules

Strong Intellectual property 4 N4 has 4 platform technologies allowing reformulation and improvement of a wide range of existing drugs OPAL IPCocrysNuvacNuvec Wide range of patents drafted by ex GSK head of patents Patent from Bradford University to manufacture cocrystals using Hot Melt extrusion Silica nano particles designed to improve sub unit vaccines Silica nano particle delivery platform for mRNA and pDNA molecules 45 patents filed for Improved version of sildenafil Novel cocrystals of sildenafil Single dose Hepatits B vaccine Novel vector for improved mRNA and pDNA protection and transfection Sub unit vaccines for rare diseases, zika, dengue, lassa, ebola and many others

Improved Viagra (combined OPAL & Cocrys) 5 Viagra (sildenafil) formulated for different use to current indication –Developed as cardio drug before erectile dysfunction discovered –As a consequence it takes one hour before drug takes effect –4 hour half life –Use needs careful planning Viagra “Plus” –Fast onset of action but also longer lasting –Therapeutic window maintained dose to dose

Improved Viagra (combined OPAL & Cocrys) 6 Viagra off patent most countries and facing strong competition Pfizer switching Viagra over the counter N4 filed 45 patents for improved Sildenafil - incredibly strong IP protection Global market size for erectile dysfunction $4.5bn Viagra (sildenafil) formulated for different use to current indication –Developed as cardio drug before erectile dysfunction discovered –As a consequence it takes one hour before drug takes effect –4 hour half life –Use needs careful planning Viagra “Plus” –Fast onset of action but also longer lasting –Therapeutic window maintained dose to dose

Cocrys ™ Patented process to use Hot Melt extrusion to produce co-crystals 7 Insoluble drug (Viagra) is combined with a co-former to alter its rate of dissolution

Cocrys ™ Patented process to use Hot Melt extrusion to produce co-crystals 8 Insoluble drug (Viagra) is combined with a co-former to alter its rate of dissolution The drug and co-former are blended together and temperature and sheer are used to fuse them together at their interface to create co-crystals of the drug. Resultant co-crystals are stable due to their strong bond and can be commercially manufactured using continuous batch production.

Nuvac® Nano silica particles with high surface area:volume ratio 9

Nuvac® Nano silica particles with high surface area:volume ratio –Imagine practise golf balls, nuvac controls the pore size to allow antigen loading inside the vesicle and delayed release of the antigen 10

Nuvac® Nano silica particles with high surface area:volume ratio –Imagine practise golf balls, nuvac controls the pore size to allow antigen loading inside the vesicle and delayed release of the antigen Resulting immune reaction is immediate and long lasting removing the need for repeat doses –Single injection to maintain immunity –Natural adjuvant, no need for Alum –Thermally stable 11

Nuvec™ Nano silica particles designed to look like a rambutan fruit 12

Nuvec™ Nano silica particles designed to look like a rambutan fruit Allows pDNA and mRNA to hook to the silica spikes 13

Nuvec™ Nano silica particles designed to look like a virus –Allows pDNA and mRNA to hook to the silica spikes Vector plays dual role –protects the molecule on its pathway to the cell –Good cellular transfection observed 14

Nuvec™ Nano silica particles designed to look like a virus –Allows pDNA and mRNA to hook to the silica spikes Vector plays dual role –protects the molecule on its pathway to the cell –Good cellular transfection observed –Nuvec can be optimised for safe and effective delivery of pDNA and mRNA to targeted cancer cells 15

Summary 16 Strong intellectual property Company individual special investment vehicle opportunities –Investments ranging from £2m to £10m+ Improved Viagra alone worth over £250m Immediate investment opportunities for –Improved Sildenafil –Single dose Hepatitis B –Rare disease single dose sub unit vaccines –pDNA and mRNA delivery vectors