ABO Presentation

Background of Ultraviolet (UV) and high energy visible (HEV)/blue light

Light is both beneficial and harmful to vision and health Harmful Role Cumulative damage to eye tissues UV damage to cornea and lens Implicated in cataracts and pterygium Cumulative damage to the retina Blue light, at certain wavelengths, causes damage to the retina Implicated in age-related macular degeneration (AMD) Essential Role Visual functions Visual acuity Color perception Contrast sensitivity Non-visual functions Sleep/wake cycle Memory and mood Hormonal balance

Dangers of uv light 100nm-380nm UVC 100-280 UVB 280-315 UVA 315-380* UV light damages the eyes just like it damage the skin Daily UV exposure adds up over time and can cause irreversible damage to the eyes UV is a major risk factor in many severe eye diseases, including cataract Surgery is the only solution to cataract 20 million cataract procedures every year in the world *ISO 8980-3

Dangers and benefits of hev/blue light (380nm-500nm) Dangers of Blue Light High Energy light that can induce and accelerate retinal cell damage Cumulative exposure to certain wavelengths of Blue Light can cause damage to the retina Risk factor for the development of age-related macular degeneration (AMD) Benefits of Blue Light Blue Light, however is also beneficial for our vision and overall health Visual acuity & color perception Sleep/wake cycle, mood, and memory Pupil size

Dangers of light to the eye UV BLUE LIGHT Cataract Normal amd

AMD & Cataract cases expected to DOUBLE Increasing incidence of cataract and amd cases in the us AMD & Cataract cases expected to DOUBLE in the next 30 years CATARACT POPULATION AMD POPULATION Source: http://www.nei.nih.gov/eyedata

Sources of uv and hev/blue light

sunlight On a cloudy day, up to 80% of the sun’s UV rays can pass through the clouds Blue light proportion of daylight varies between 25% and 30% Exposure to harmful light depends on the following factors: Season Time of day Geographic location Gaze direction

Artificial light Compact fluorescent lamps LEDs Contain 25% harmful Blue Light LEDs Contain 35% harmful Blue Light The cooler the white LED, the higher the blue proportion By 2020, 90% of all light sources will be LED

blue-violet light RESEARCH

Research conducted by essilor & paris vision institute Paris Vision Institute -  One of the most important research centers on eye diseases In 2008, Essilor partnered with Paris Vision Institute for a eye health research program First in-vitro tests in the ophthalmic industry with 10nm bands of HEV light exposure Visible light spectrum split into 10 nanometer bands Each band focused on retinal cells* Specific bands induced maximum retinal cell death *Based on in-vitro tests on swine retinal cells

Discovery of specific band of harmful blue-violet light TOXIC 415-455nm In partnership Paris Vision Institute, Essilor aims to offer the most complete eye protection against dangerous light including HEV. First in-vitro tests in the ophthalmic industry with 10nm bands of HEV light exposure Result: 40nm (415-455nm) of the HEV spectrum – known as Blue-Violet light – are most harmful.

Introduction to blue-violet light AMD Blue-Violet light ranges from 415 to 455 nanometers (nm) – the band of visible light most harmful to retinal cells Cumulative exposure to Blue-Violet light can lead to retinal cell death Blue-Violet light is one of the risk factors for the development of age-related macular degeneration (AMD) AMD is the leading cause of severe vision loss and legal blindness in adults over 60 There is no cure for AMD today Normal Vision AMD Vision

blue-violet light emission from led and other sources

Cognitive performance Pupillary constriction Color perception, acuity Introduction to blue-turquoise light Sleep/wake cycle Memory & mood Cognitive performance Pupillary constriction Color perception, acuity Blue-Turquoise light ranges from 465 to 495 nanometers (nm) Blue-Turquoise light is essential for: Pupillary Constriction Reflex Retina’s natural protection against light overexposure “Human biological clock” synchronization Allows the right functioning of the sleep/ wake cycle, memory, mood, etc. Visual acuity & color perception

Inadequate Blue-Turquoise light can desynchronize the sleep/wake cycle

Light scan™

NEED FOR A SELECTIVE LIGHT FILTER Selective photo-filtration HARMFUL 415-455nm ESSENTIAL 465-495nm Blue light is made up of both harmful and beneficial light Harmful: Blue-Violet Light Beneficial: Blue-Turquoise Light UV Light, that is part of the invisible light spectrum, is very harmful to eyes There is a need for a lens solution that protects eyes from the harmful light, but allows the beneficial visible light to pass through NEED FOR A SELECTIVE LIGHT FILTER

Three key features of light scan™ Light Scan™ is a patented selective No-Glare technology Key features of Light Scan: Selectively filters out harmful Blue-Violet Allows beneficial visible light, including Blue-Turquoise light, to pass through Maintains excellent transparency of the lens

No-Glare Lenses Protection Against Harmful Blue-Violet & UV Light

Front-side & back-side protection

Protection from uv & blue-violet light

Crizal® prevencia™: front-side blue-violet light deflection This graph shows the front-side reflection of Visible Light 20% Blue-Violet light deflected Blue-Turquoise transmitted Rest of visible light transmitted

Crizal® prevencia™: blue-violet light protection Protection from Blue-Violet light New No-Glare lens treatment Features Light Scan™ Selectively deflects harmful Blue-Violet light by 20% In recent lab tests, Crizal Prevencia lenses reduced retinal cell death by 25%* First No-Glare lens on the market to selectively deflect harmful Blue-Violet and UV light *Results from in-vitro tests on swine retinal cells

Crizal® prevencia™: back-side uv reflection protection

Crizal® prevencia™: uv light protection 25X MORE UV PROTECTION THAN GOING WITHOUT EYEWEAR*    Protection from UV light: E-SPF® value of 25 Provides protection from UV light reflecting from back-side of the lens Independent tests show up to 50% of UV exposure comes from the back and sides to hit the rear lens’ surface Reflects four to eight times less UV light from the backside of the lens than most leading competitive No-Glare lenses on the market today * E-SPF® is a global index rating the overall UV protection of a lens. E-SPF® was developed by Essilor International and endorsed by 3rd party experts. A lens rating of E-SPF® 25 means that an eye protected by the lens will receive 25 times less UV exposure than an unprotected eye. E-SPF® of 25 when a Crizal lens is made with lens material other than clear 1.5 plastic.

Crizal® prevencia™: at a glance Light Scan™ Deflects 20% of harmful Blue-Violet light and in recent lab tests, reduced retinal cell death by 25%*+ Allows beneficial Blue-Turquoise light to pass through Maintains excellent transparency for optimal vision E-SPF® value of 25 Features the same level of protection against back-side UV reflection as all Crizal No-Glare lenses 25x more UV protection than going without eyewear Features complete protection against the enemies of clear vision: glare, scratches, smudge, dust and water *Results from in-vitro tests on swine retinal cells +25% less light induced retinal cell death rate versus a standard clear lens. In in vitro experiments conducted by Essilor and Paris Vision Institute, Retinal Pigment Epithelium cells were exposed to Blue-Violet light, reproducing the physiological exposure to sunlight of the 40 year old eye.

Who needs most protection? HIGH Exposure to White LED or Fluorescent Light Bulbs in offices/homes Frequent user of LED computer monitor, Tablet and Smart Phone At-risk for AMD (family history, smokers, etc.)

In conclusion Educate at-risk AMD patients on the need to protect their eyes from harmful Blue-Violet light Recommend Crizal® Prevencia™ lenses to your at-risk AMD patients to add another level of protection Discuss the need to protect eyes from Blue-Violet light emitted from modern digital devices Discuss their visual needs by asking open-ended questions, such as: How do you protect your eyes on a daily basis? Do you have a family history for macular degeneration/AMD? How much time do you spend in front of digital devices? How are you currently protecting your eyes against UV damage?

Thank you