2nd National Health Policy & Clinical Practice Conference Westin Savannah Golf Harbor Resort & Spa March 31-April 2, 2016

SPONSOR APPRECIATION

Improving Health Outcomes with Ginger and Turmeric Health Policy and Clinical Practice Conference Savannah, GA March 31 st 2016 Ross Harding CEO Verdant Kitchen Copyright Verdant Kitchen 2016©

Verdant Kitchen™ is a gourmet and wellness company specializing in Ginger and Turmeric. We use select ingredients including spices from our USDA Organic farms to deliver naturally complex nutrition™. Disclaimer – Verdant Kitchen™ is a food and dietary supplement company. Nothing in this presentation is designed to provide medical advice. Statements with regard to the use of products for human health is presented as an academic review of published work and public opinion. * Any statements (regarding health) have not been evaluated by the Food and Drug Administration. Any reference to products (regarding health) are not intended to diagnose, treat, cure or prevent any disease.

Ginger and Turmeric – ancient spices with over 7,000 years of recorded use. Subtropical, rhizomes propagating herbaceous perennials, native to southern India and South East Asia. Both belong to the Zingiberaceae family which contains 53 genera and 1300 species. The family includes edible, medicinal and ornamental varieties. Many contain diverse and complex blends of phytochemicals including polyphenols, essential oils, vitamins and minerals.

The History of Ginger is the history of world trade and empire. 1750’s 1550’s 1300 AD 122 AD 1500 BC

Ginger and Turmeric as food – generally safe with thousands of years of human and animal consumption with low toxicity at dietary use rates of up to and exceeding 1000mg per day of dried roots.

Ginger and Turmeric as a dietary supplement and medicine. PubMed has 3538 research articles listed for Turmeric including 114 clinical trials and 8732 articles on one of its active polyphenols Curcumin 2434 research articles listed for Ginger including 159 clinical trials Low levels of colon rectal cancer in India 1 High Levels of Turmeric Consumption in India Research and marketing pour into Turmeric and Ginger High levels of Curcumin in Turmeric 2 Perhaps the reasoning is not sound but the result has been positive

Ginger and Turmeric as a dietary supplement and medicine. Opportunities for successful health outcomes: With such a wide ranging body of in vitro, in vivo, and human clinical trials, Turmeric and Ginger have been ascribed many potential health and dietary benefits In a recent MD Anderson, University of Texas review of ongoing study with respect to Turmeric “antioxidant, anti- inflammatory, antibacterial, antiviral, antifungal, anticancer.. various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer” 3

Possible Modes of Action of Turmeric Modulation of Inflammatory response through inhibition of COX-2, LOX, NF- kappaB and AGE 4 Anti oxidant reaction to remove and reduce excess free radicals and improve liver and renal function and ability to provide detoxification and elimination 5 Possible Modes of Action of Ginger Modulation of Inflammatory repose Modulation and disruption of pathways that lead to nausea and vomiting 6 Modulation of clotting, blood sugar levels and blood pressure Both Ginger and Turmeric are complex blends that include multiple phytochemicals including polyphenols, essential oils and vitamins. This complex mixture often appears to lead to multiple impacted pathways and outcomes. Primary phytochemicals and their associated breakdown products have system wide impacts Multiple pathways impacted – difficult to study isolated reactions. Complex conjugates may have impacts beyond individual species

Concerns Bioavailability, Bio reactivity and Degradation/Removal The phytochemicals have widely varying gut adsorption rates, time based blood serum levels and degradation and removal pathways. The rates of movement through the body are no doubt impacted by the physical form, the preparation and how the materials are ingested. Active Ingredients vs Complex Natural Nutrition™ Academic study and Marketing are draw to simple answers. Turmeric is not simply Curcumin just as a Banana is not simply Potassium A little is good so a lot must be great! Toxicity and drug interactions have been based on the natural bioavailability of phytochemicals in the naturally occurring rhizomes The push to extract single ingredients, concentrate them, manipulate their bio availability may lead to pathway and pharmaceutical interactions that are unknown

Opportunities for successful health outcomes – a recipe for an active healthy life Inflammation is a natural and necessary part of our bodies active function. It heals and protects. Excessive, repeated and chronic inflammation causes pain, damage and a cascade of bad outcomes Reduce pro inflammatory inputs Pro Inflammatory foods Repetitive injury Stress Obesity Poor Nutrition Increase anti inflammatory inputs Plant based polyphenols and antioxidants Moderate exercise Positive thought, joy and relaxation Active Modulation of Inflammation and disease reduction through naturally complex nutrition™ and lifestyle choices

Summary Low Toxicity Ancient spices that have been in constant use in the human food chain for over 7000 years Few negative interactions when taken at active levels found in food sources Delicious Adds flavor and colors to food. Imparts joy in the consumer, a powerful health promoter. Broad Positive System Impacts * Evidence in research of Anti inflammatory, Anti oxidant, improved liver function, anti viral, anti cancer, reduced nausea, decreased blood sugar, decreased clotting, decreased hyper tension Available in a wide range of cost effective physicals forms Fresh rhizomes, teas, dried spice, marinades, sauces, beverages, supplements

References 1.Cancer Risk and Diet in India: Sinha, R et al. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Chemical Composition and product quality control of turmeric: Shiyou Li et al. Stephen F Austin State University, Temple School of Forestry. Pharmaceutical Crops Curcumin, a component of golden spice: From bedside to bench and back: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center 4.Plant-derived health: the effects of turmeric and curcuminoids: Begmark, s et al. Institute of Hepatology, University College London Medical School, London. 5.Protective Role of Dietary Curcumin in the Prevention of the Oxidative Stress Induced by Chronic Alcohol with respect to Hepatic Injury and Antiatherogenic Markers:Varatharajalu R, Lipid Research Laboratory, VA Medical Center and Department of Biochemistry and Molecular Medicine, The George Washington University 6.Ginger-Mechanism of Action in Chemotherapy-induced Nausea and Vomiting: A Review: Marx, W, Centre of Dietetics Research, University of Queensland, St Lucia, QLD, Australia