IDeA Program Update COBRE PI Meeting June 28, 2012 Yanping Liu, MD. PhD Medical Officer National Institute of General Medical Sciences National Institutes.

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IDeA Program Update COBRE PI Meeting June 28, 2012 Yanping Liu, MD. PhD Medical Officer National Institute of General Medical Sciences National Institutes of Health

NIGMS September 2011 IDeA Programs COBREINBRE IDeA-CTR Co-Funding

NIGMS Research Infrastructure Research Projects (Junior Investigators) Research Infrastructure Research Projects (Junior and Senior Investigators) Research Cores that are essential for basic and clinical research Pilot Project Program Develop advanced research infrastructure and a critical mass of investigators in thematic areas Transition

NIGMS September 2011 COBRE Program Announcements Phase I PAR Phase II PAR 12- Phase III PAR Receipt DateFeb 21, 2013 and 2014 September 2012, 2013 and 2014 July 20, 2012 Review DateMay/June, 2013 and 2014 Jan/Feb, 2013, 2014, and 2015 Oct./Nov Council ReviewOct and 2014 May 2013, 2014, and 2015 Jan, 2013

NIGMS

September 2011 Key Elements of COBRE Phase I  The administrative leadership of PI and overall potential of PI for developing an independent, multi-disciplinary center. o Enhance research capacity, o Select research projects, o Set milestones o Implement evaluation strategies.  The mentoring plan for promoting young investigators to achieve independent status.  Research core facilities: o Demonstrating how each core will serve the scientific needs of the individual projects and how the cores will impact the development of the center.  Research Projects: o Consistent with the overall center theme, o The potential and ability of project leader to achieve independent status, o The academic qualifications and biomedical expertise of the project investigators are appropriate and sufficient for research productivity. Development

NIGMS September 2011  The progress of the center in COBRE phase I o Acquiring research support o Publications in peer reviewed journals o Development of appropriate infrastructure  The administrative leadership of the PI o Strengthen biomedical research capacity o Select research projects led by Junior or Senior investigators o The strategy of mentoring plan  The proposed 5 year plan for continuing the development of early career investigators and moving the center toward an independent and sustainable center Key Elements of COBRE Phase II Strengthen

NIGMS September 2011  The achievements of the center in COBRE phase I and phase II o Acquiring research support o Publications in peer reviewed journals o Development of appropriate infrastructure  Research Core Facilities o The plan for sustaining the cores, o How the cores serve and/or improve the research infrastructure of the institution, o The operating procedures of each core, o Institutional commitment to support and maintain the proposed facilities.  Pilot Project Program o A plan for soliciting, prioritizing, and reviewing the projects. o Oversight and evaluation procedures. o The assurance that all projects will comply fully with federal policies, rules, and guidelines for research involving human subjects and/or vertebrate animals. Key Elements of COBRE Phase III Sustain and Transition

NIGMS

September 2011 Breadth of COBRE-Supported Science (Phase 1 and Phase 2) Immunology (9) Proteomics and Genomic (8) Infectious Disease (5) Oral Health (5) WMHHD (4) ES (2) MB (3) BB (1) DD (3) LBD (2) PB (2) SCB (3) Cardiovascular Diseases (11) Cancer (9) Neuroscience (18) Basic Research Clinic Research CBPR

NIGMS September 2011 Role of Pituitary adenylate cyclase-activating polypeptide (PACAP) in human Post-traumatic Stress Disorder COBRE, University of Vermont – PI: Dr. Parsons  Perturbations in the PACAP–PAC1 pathway are involved in abnormal stress responses underlying post-traumatic stress disorder.  Future work targeting the PACAP–PAC1 receptor system may lead to novel and robust biomarkers for further mechanistic understanding of post-traumatic stress disorder.

NIGMS September 2011 Provide support to undergraduate students, serve as “pipeline” to health research Increase research support to faculty, postdoctoral fellow and students Enhance science and technology knowledge of the state's workforce. Build a statewide multi- disciplinary research network Biomedical Research Infrastructure Networks (BRIN), began in Re-competed in 2004 as IDeA Networks of Biomedical Research Excellence (INBRE). INBRE Program

NIGMS September 2011 Breadth of INBRE-Supported Science Microbiology & Infectious Diseases (63) Cell & Dev. Biology (46) Cancer (42) Neuroscience (33) Biotech (23) EHT (23) GG (15) CVS (11) WRH (10) BI (9) Other (9) DOM (8) Re (5) MH (5) BJ (4) Im (3) He (2) EHT: Environmental Health & Toxicology GG: Genetics & Genomics CVS: Cardiovascular Disease WHR: Women &Reproductive Health BI: Bioinformatics DOM: Diabetes/Obesity/Metabolism Re: Respiratory MH: Mental Health BJ: Bones/Joints Im: Immunology He: Hematology

NIGMS September 2011 Multiple Sclerosis in Only One Identical Twin: Nature vs. Nurture New Mexico INBRE PI: Jeffery Arterburn  First integrated genome survey comparing healthy and diseased individuals.  First genome sequences of females, twins or persons with autoimmune disease.  First ten adult epigenome sequences showing inherited DNA modifications, including differences between twins, differences between unrelated individuals and differences between different body tissues

NIGMS September 2011 Howard Hughes Med. Ins Emory U. U. Of Vermont U. Of Miami Genetec Inc. NCGR UCSF Illumina Inc. Stanford Wayne State Med. Sch. Network and Collaboration Produce Outstanding Scientific Products Institutions States

NIGMS September 2011 Phase II (43) Phase I (22) (24) IDeA Programs (2012) 821ResearchProjects 430ResearchProjects

NIGMS September 2011 Overall Impact of IDeA Program $424 $1, Fold

NIGMS September 2011 COBRE INBRE Research Impact of IDeA Program InvestigatorsResearch Project

NIGMS September 2011 COBRE INBRE R01 R21 PublicationsResearch Grants Research Impact of IDeA Program

NIGMS

September 2011 IDeA Co-funding (FY2012) IDeA co-funds awards to support R01 grant applications to NIH Institutes and Centers from investigators within IDeA eligible states. This activity was highlighted in the NIH fiscal year 2012 appropriation language. Applicants whose proposals received excellent ratings through the peer review process but fell short of the Institute’s or Center’s pay line. IDeA provides 70% or up to $260,000 for each of the first two years of a selected co-funded R01 award.

NIGMS