aequatus-vis Anil Thanki Scientific Programmer –

RECAP Aequatus

Homology and Phylogeny ■Homology is existence of shared ancestry between a pair of structures, or genes, in different species. ■The phylogenetic information inferred from the study of homologous genes helps us to understand the evolution of gene

Aequatus ■Aequatus is an open-source web based tool to visualise homologous genes with phylogenetic tree. ■Aequatus reads data directly from Ensembl Compara and Ensembl Core Databases ■ ■GitHub:

monoamine oxidase

Aequatus Homologous Genes with shared exon monoamine oxidase

Aequatus Gene monoamine oxidase

Aequatus Reference information monoamine oxidase

Reference information Aequatus visualises similarity amongst homologous genes along with the event type responsible for existence of the gene, for example speciation, duplication, gene-split etc. Also indicates insertions and deletions With user-friendly interactions and viewing options monoamine oxidase

aequatus-vis

■aequatus-vis is a JavaScript plugin to visualise homologous genes through alignment and phylogeny information. ■It preserves interactive functionality of Aequatus ■It has an ability to integration with countless web based

aequatus-vis 1.Gene Tree JSON / Newick 2.Gene structural Info JSON format returned from e! server ■aequatus-vis takes gene tree and gene structural information as input ■Gene tree in either Newick or JSON from e! server ■Gene structures in JSON format from e! server

EXAMPLES

Example of visualising homologous genes in Aequatus using aequauts-vis Next update

Aequatus e! Rest Example of visualising homologous genes fetched from e! Rest API in Aequatus using aequatus-vis Testing

Example of visualising homologous genes in Galaxy using aequatus-vis Pull request

TGAC Robert Davey Sarah Ayling Nicola Soranzo Contact Javier Herrero UCL Cancer Institute, UK Matthieu Muffato EBI-EMBL, UK

Thank you ■Questions? ■Suggestions? ■Advice? ■Potential Users / collaborators