Creating a healthcare system to FIT the patient – Patient-centered translation of evidence into practice Nilay Shah Division of Health Care Policy and Research And Knowledge and Evaluation Research (KER) Unit Mayo Clinic
Disclosures Funding provided by: – AHRQ: R18 HS019214; R18 HS – NIDDK: R34 DK84009 – Foundation for Informed Medical Decision Making (FIMDM) – American Diabetes Association (ADA) – Mayo Clinic Foundation for Medical Education and Research – Mayo Clinic CTSA
EBM KT Glasziou and Haynes ACP JC 2005
A survey of 627 US primary care clinicians Sirovich BE et al. Arch Intern Med % of my patients get too much care 50% of primary care docs are too aggressive 60% of specialists are too aggressive 35% practice much more aggressively than what they would like
Treatment of Low Grade Prostate Cancer
Rates of Mammography Screening Among Younger Women
Key problem: Do not follow advice Poor health despite cost and side effects Complicated patient-clinician relationship Wasted or misallocated healthcare resources: US$ 290b (100b in avoidable hospitalizations) Cutler and Everett NEJM /NEJMp
Encounter Research NEED WANT CAN APPROPRIATE DESIRABLE FEASIBLE
Cumulative complexity model Shippee et al 2011 Workload Capacity access use self-care Outcomes Burden of treatment Burden of illness
The work of being a chronic patient Self-reported 48 min / day incomplete “not enough time” Desirable (ADA) 122 minutes/day + admin 143 minutes/day Russell LB et al. JFP 2005; 54: 52-56
Superusers Are heavier* users of visits, lab tests, imaging, pharmacy visits, number of medications 3 conditions: 2x 4 conditions: 4x 5+ conditions: 9x vs. patients with diabetes and 1-2 conditions, adjusted by sex and age, in commercially insured patients * top 25% Shippee et al. In preparation
Imagine…. 62-year old woman…. Diabetes: Metformin 2x/day, SU 1x/day Hypertension: Diuretic and ACE-I 1/day Hypercholesterolemia: statin 1/day Osteoporosis: Bisphosphonate 1/week Chronic pain: NSAID 2x/day; narcotics as needed Asthma: oral leukotriene 1x/day OTC: Aspirin 1x/day Other health care requirements: testing and screening; specialists Caregiver... 16
Minimally disruptive healthcare Health care delivery designed to reduce the burden of treatment on patients while pursuing patient goals May CR, Montori VM, Mair FS. BMJ 2009; 339:b2803 Want NeedCan
The work of being a chronic patient Sense-making workOrganizing work and enrolling others Doing the work Reflection, monitoring, appraisal
Minimally disruptive healthcare Burden of treatment Coordination of care Comorbidity in clinical evidence and guidelines Prioritize from the patient’s perspective
Encounter Research
Evidence synthesis Observations clinical encounter Designers Study team Patients advisory groups Clinicians Initial prototype Field testing Modified prototype Final Decision aid Evaluation
Diabetes Cards Nature of diabetes medication discussions Summarizing the research evidence Iterative process – Choice Architecture
“Baseball Cards”
“Narrative Cards”
More helpful Improved knowledge Increased patient involvement No difference in adherence (perfect adherence in control gr) No significant impact on HbA1c levels Mullan RJ et al. Archives of Internal Medicine 2009
Final Iteration: Issue CardsIssue Cards
Risk-Treatment Paradox Ko, Mamdani and Alter JAMA 2004
Improved Knowledge Risk estimation Comfort with the decision Total trust Action (70% fewer Rx in low risk patients) Short-term adherence Weymiller et al. Arch Intern Med 2007
Adherence after Initiating Bisphosphonates Source: Rabenda et. al Osteoporosis 2008
Association Between Adherence and Risk of Fracture
>75% MDs found helpful + 1 min to consultation time Improved knowledge & risk estimate No change in comfort or trust Increased patient involvement Montori VM et al. Am J Med 2011 Osteoporosis Choice
Decision to Start Bisphosphonate
Recommended “Medication Bundle” after an AMI Shah ND, et al. Am J Med 2009
Structural Intervention Remove copay on recommended medications Choudhry N et. al. NEJM 2011
Knowledge Transfer 4-5 min to consultation time Improved knowledge & risk estimate No change in comfort or trust High-levels of patient involvement Increased satisfaction
Knowledge of Risks and Benefits
Adherence to Medications
A Case Study A 63 y.o. woman presents to the ED with pain in the neck going to her left arm. Intermittent sharp twinges of pain in her chest. No ischemic changes on ECG; serial cardiac troponins were negative PMH: Hypertension, Migraines, Breast cancer Former smoker What would you want to do if you were her?
Hospital or ED Observation Unit Admission
Hess et. al Circ CQO 2012
Summary of Findings: Chest Pain Choice Improved knowledge Comfort with the decision Greater level of engagement High levels of satisfaction
Management Decisions
Evidence Synthesis
The Depression Choice Decision Aid
Experience WorkSettingEvaluation Statin ChoicePrimary + specialty care Feasible, effective, implemented in EHR, web-based, multicenter trial DM2 Med ChoicePrimary careFeasible, effective, multicenter trial, web-based Aspirin ChoicePrimary care (group)Not evaluated Depression ChoicePrimary careOngoing trial Genomic ChoiceExperimentalDesign phase Osteoporosis ChoicePrimary careFeasible, effective, EHR ICD ChoiceSpecialty careDesign phase Smoking choicePrimary careDesign phase Chest Pain ChoiceEmergencyFeasible, effective, multicenter trial AMI ChoiceHospital wardFeasible, effective, multicenter trial Hypertensione-primary careDesign phase RosiglitazoneGeneralNot evaluated Prostate cancer screening and early treatment General (tablet)Design phase PCI vs. medical therapySpecialty careOngoing Trial Mammography < 40Primary careDesign phase Menopause symptomsPrimary careDesign phase
Our work Since clinicians 50+ sites patients Patient and Family councils = key role Funding: Mayo, AHRQ, NIH, benefactors, and foundations. No for-profit funding.
Summary of experience Age: (avg 65) Primary care, ED, hospital, specialty care 74-90% clinicians want to use tool again Adds minutes to consultation 60% fidelity 20% improvement in knowledge 17% improvement in patient involvement Variable clinical outcomes
Implementation
Statin Decision Aid
Lessons learnt User-centered design happens in the field, takes multiple iterations and expertise Challenges with evidence synthesis and changing evidence Testing decision aids in usual clinical settings is tough: decision moments are unpredictable Repeated use for chronic decisions has been difficult to study in efficacy trials
Lessons learnt Decision aids have increased knowledge and patient involvement in the decision consistently The impact on improving adherence to medications is mixed Clinicians and patients have reported high-levels of satisfaction (in trial settings); however culture is important
Work in progress Better understanding of the level of evidence necessary to embed into practice Challenges of broad implementation into routine practice and repeated use Right place and time to engage patients with chronic conditions Much broader work around designing a minimally disruptive system
7 th International Shared Decision Making Conference Lima, Perú - June