Figure 1 A B 4µM8µM16µM32µM 0 NS ** *** Infected and 4 µ M STS treated Infected and 32 µM STS treated Mock Infected and 4 µM STS treated Mock Infected and 32 µ M STS treated Cleaved PARP Full-length PARP

Figure 2 Infected Mock infected Caspase 3 Cleaved Caspase 3 B C A Caspase 9 Cleaved Caspase 9 Infected Mock infected D ***

Fig 3 DetachedAttached Mock Infected STS Treated CCHFV Infected Mock treated CCHFV Infected STS Treated abcd A B Attached Cells Detached Cells ***

Activated caspase 3 (fluorescence unit) * Fig 4 flag-Bax myc-N A * B anti-PARP anti-flag anti-myc anti-actin

Fig 5 Full-length Bid Truncated Bid Mock-Infected 24hr.p.i 48 hr.p.i 24hr.p.i 48 hr.p.i Mock-Infected Infected Detached cellsAttached cells

bca Full-length PARP Cleaved PARP Fig 6 A B ****** C