Date of download: 5/29/2016 From: Statins and Cognitive Function: A Systematic Review Ann Intern Med. 2013;159(10): doi: / Summary of evidence search and selection. RCT = randomized, controlled trial. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 5/29/2016 From: Statins and Cognitive Function: A Systematic Review Ann Intern Med. 2013;159(10): doi: / Meta-analyses of risk ratios from cohort studies for dementia, Alzheimer disease, and mild cognitive impairment. NA = not available.* Pooled analysis as follows: Wolozin et al, 2007: atorvastatin, lovastatin, simvastatin; Hippisley-Cox and Coupland, 2010: atorvastatin/men, atorvastatin/women, fluvastatin/men, fluvastatin/women, pravastatin/men, pravastatin/women, rosuvastatin/men, rosuvastatin/women, simvastatin/men, simvastatin/women; Ancelin et al, 2012: men, women. Adjustments as follows: Rea et al, 2005: age, sex, education, baseline modified Mini-Mental State Examination, cardiovascular disease, cerebrovascular disease, alcohol use; Zandi et al, 2005: age, sex, education, number of ApoE4 alleles, hypertension, diabetes mellitus; Szwast et al, 2007: age, sex, education, ApoE4; Wolozin et al, 2007: age, cardiovascular disease, hypertension, diabetes mellitus, Charlson Index (a measure of chronic disease); Smeeth et al, 2008: age, sex, likelihood of statin use, date of statin initiation, new diagnoses or drug therapies; Hippisley-Cox and Coupland, 2010: age, cardiovascular disease, cerebrovascular disease, diabetes mellitus, depression, use of tricyclic antidepressants or selective serotonin reuptake inhibitors, body mass index; Beydoun et al, 2011: age, sex, race, education, cardiovascular disease, cerebrovascular disease, hypertension, diabetes mellitus, atrial fibrillation, dyslipidemia, body mass index, blood pressure, smoking status; Parikh et al, 2011: medical comorbid conditions defined by the Centers for Medicare & Medicaid Services Hierarchical Condition Categories risk-adjustment model; Ancelin et al, 2012: age, location, education; Bettermann et al, 2012: age, sex, race, education, ApoE4, cardiovascular disease, cerebrovascular disease, baseline mild cognitive impairment, treatment group, location; Sparks, 2008: age, sex, education, ApoE4; Haag et al, 2009: age, sex, education, ApoE4, cardiovascular disease, cerebrovascular disease, diabetes mellitus, other lipid-lowering agents, smoking status, blood pressure, body mass index, total cholesterol; Li et al, 2010: age, cohort, sex, race, education, ApoE4, baseline Cognitive Abilities Screening Instrument, cardiovascular disease, cerebrovascular disease, hypertension, diabetes mellitus, other lipid- lowering agents, smoking status, body mass index; Yaffe et al, 2002: age, education, treatment group, coronary artery bypass grafting, total cholesterol, smoking status; Cramer et al, 2008: education, ApoE4, cerebrovascular disease, diabetes mellitus, smoking status. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 5/29/2016 From: Statins and Cognitive Function: A Systematic Review Ann Intern Med. 2013;159(10): doi: / Meta-analyses of risk ratios from case–control studies (top ) and cross-sectional studies (bottom) for dementia, Alzheimer disease, and mild cognitive impairment. NA = not available.* Adjustments as follows: Jick et al, 2000: age, sex, cardiovascular disease, cerebrovascular disease, hypertension, diabetes mellitus, date of dementia/Alzheimer disease diagnosis, years of recorded history in General Practice Research Database, practice, body mass index, smoking status; Rockwood et al, 2002: unadjusted results reported; Zamrini et al, 2004: cardiovascular disease, cerebrovascular disease, hypertension, diabetes mellitus, lipid metabolism disorders; Green et al, 2006: age, sex, race, education; Rockwood et al, 2007: sex, education, self-rated health; Rodriguez et al, 2002: age, sex, education, cardiovascular disease, cerebrovascular disease, hypertension, alcohol use, smoking status, primary care physician visit; Wolozin et al, 2000: unadjusted results reported; Carlsson et al, 2009: age, sex, education, mean carotid intima– media thickness; Glasser et al, 2010: age, sex, race, education, income, cardiovascular disease. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians