Opioid Pain Management 2015 Malcolm Butler MD Medical Director Columbia Valley Community Health.

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Presentation transcript:

Opioid Pain Management 2015 Malcolm Butler MD Medical Director Columbia Valley Community Health

Goals Where we were / Where we are The new Washington State guidelines – Opioids are the “great unmasker” of OUD Aberrant behavior is a big red flag Prescribing larger doses is NOT being compassionate – There is NO safe dose of chronic opioids – Opioids are sixth line therapy in chronic pain – Stratify risk, measure interference with function, minimize dose

Where We Were 2005 – “Opioids are safe and effective in the management of chronic pain.” – Pain should be assessed at every visit – Escalating crisis, huge “demand” for Rx opioids – 23% of CVCH mortalities were opioid related – Community rallied to redefine “appropriate” opioid prescribing

Where We Are State % Death Rates related to Opioids

Where We Are

County statistics CVCH statistics

AMDG Guideline First published 2007 Second edition 2010 Third edition published June 2015 – Combined effort of Washington State Labor and Industries, DSHS, and University of Washington – 50 Medical Directors, Clinicians, Academicians If you manage pain: A MUST READ

Salient Points in the New Guideline Opioids are “the great unmasker” of occult Opioid Use Disorder (DSM-V) – Guideline defines break points between acute, sub-acute, and chronic pain management – Each is an opportunity to recognize occult Opioid Use Disorder (OUD) You need to identify high risk populations and be extremely cautious with opioids Use the validated tools provided to measure, track, and manage pain, function, interference

Salient Points Opioids are 6 th line therapy in Chronic Pain – Appropriate only in select populations – You must develop capacity for other modalities There is no safe dose of opioids – Taper as low as possible – Discontinue with signs of Opioid Use Disorder New sections for special populations

6 th Line Therapy Prior guidelines focused on “safe opioid prescribing.” This guideline recognizes that “there is no completely safe opioid dose.” Because there is NO evidence of improved long term function or pain control, and AMPLE evidence of harm, prescribers should “proceed with caution” when considering starting opioids in chronic pain.

Fun Facts Risk ratio of developing Opioid Use Disorder in patients on high dose opioids (>120mg MED/d) is 122. Over 60% of patients taking opioids for at least 3 months are still on opioids 5 years later. Receiving one week of opioids for acute Low Back Pain doubles the risk for long-term disability. Adults with a history of depression or substance use disorder are 4 times more likely to receive opioids for their chronic pain.

Fun Facts

1:5 patients on chronic opioids will develop Opioid Use Disorder. 33% of cancer survivors suffer from chronic pain related to their cancer treatments. – Neuropathy, fibrosis from radiation, lymphedema – And worsening pain may signal a recurrence, so a tough issue when using opioids

Skimming the Surface All Pain Phases – Recognize “Clinically Meaningful Improvement in Function” (CMIF) By definition, must be at least 30% (7/10 -> 10/10) Decreased PAIN intensity in the absence of improved function is NOT clinically meaningful – “Continuing to prescribe opioids in the absence of CMIF is NOT considered appropriate care.” – New focus on “Pain Interference”

Skimming the Surface

Expect patients to resume normal activities in a matter of weeks after an acute pain episode. – “Most don’t finish their first prescription” – Request for a second prescription demands re- evaluation and is a red flag warning for OUD Evaluate pain and function with validated instruments (questionnaires) at: – End of acute phase (6 weeks) – End of sub-acute phase (12 weeks) – Every visit in chronic pain

Skimming the Surface Avoid chronic opioids in high risk populations: – Significant respiratory disease/failure – Current or past substance use disorder – History of opioid overdose – Patterns of aberrant behavior Use great caution and consider naloxone: – Mental health disorder – Family history of substance use disorder – Current use of benzodiazepines – Tobacco use Do not escalate above 120mg MED without “pain specialist” consultation.

Skimming the Surface Excellent section on non-opioid options for pain management – When/how to assess and re-assess chronic pain – Sleep hygiene – Mindfulness, stress reduction – Physical therapy – Groups – Non opioid analgesics

Diving a Little Deeper Acute pain management “In general, reserve opioids for acute pain resulting from severe injuries or conditions when alternatives are ineffective or contraindicated. If opioids are prescribed, it should be at the lowest dose for the shortest duration possible (usually < 14 days). The use of opioids for non-specific low back pain, headaches, and fibromyalgia is not supported by evidence.”

Diving a Little Deeper Acute pain management – Pre-load the patient with appropriate expectations: Pain is OK. It is normal. We expect it. It will improve. “Your Ibuprofen will cover about 70% of your pain. Keep your Oxycodone for when your pain is especially severe. I anticipate you will need to use it three times a day for the first few days, then once or twice a day until I see you back.” – Expect patients to resume normal activities in a matter of weeks after an acute pain episode.

Diving a Little Deeper Remember “the great unmasker” of Opioid Use Disorder – A request for a refill in acute pain is a big red flag Check your state’s Prescription Monitoring Program – Questions about that? Pull out the pain interference questionnaire See them back frequently – you are the therapy – Prescribing opioids for acute pain beyond six weeks is NOT being kind or compassionate Most likely it is feeding Opioid Use Disorder In all cases it requires thorough re-evaluation Taper off opioids if there is no evidence of clinically meaningful improvement in function

Diving a Little Deeper Sub-Acute phase (6-12 weeks post surgery) – Query the Prescription Monitoring Program – Screen for depression (PHQ-9), anxiety (GAD-7), PTSD (PC-PTSD), Substance Use Disorder (various) Co-morbid behavioral illness must be treated aggressively or pain will not improve – Check Urine Drug Screen Do not continue opioids if any unexpected findings (There is a whole section on how to evaluate UDS)

Diving a Little Deeper Sub-Acute phase (6-12 weeks) – Do not continue opioids if: There is no clinically meaningful improvement in function and pain Opioids resulted in a severe adverse outcome Patient has current or history of substance use disorder Cannabis – Guideline is purposefully vague – “If UDS positive for cannabis, assess for cannabis use disorder.” – “It would be prudent to have a policy regarding the concomitant use of cannabis and opioids.”

Diving a Little Deeper Pre-operative management – Include opioid misuse risk assessment, including PMP query, in pre-op evaluation – Consider risk of post-operative over sedation, respiratory depression, etc. – With pre-existing chronic pain, surgeon should coordinate post-op pain management with outpatient opioid prescriber – Pre-load patient with expectation of who will manage opioids post operatively – Transition to oral opioids ASAP post-op

Diving a Little Deeper Peri-operative management: “Do not discharge patient with more than a two week supply of opioids. Many surgeries may require less.” Vicodin 5/325, #12, Refill: 1

Diving a Little Deeper Chronic Pain – Opioids are 6 th line therapy Think Prednisone for otitis media. – Monitor and continue opioids ONLY if there is sustained Clinically Meaningful Improvement in Function (CMIF) and no serious adverse outcomes Escalate dose ONLY if CMIF is demonstrated If they arrive on high dose opioids, taper until CMIF is lost – Consent re: dangers, expectations, policies – “Use extreme caution” with behavioral illness, addiction, pulmonary compromise, hx of substance use disorder, etc.

Diving a Little Deeper Chronic Pain “management hygiene:” – Prescribe in 7 day increments – Use tools to assess CMIF at each visit – Check your state’s PMP, and UDS at a frequency defined by patient’s risk of misuse (1, 3, or 6 mo intervals) – Monitor for adverse outcomes at each visit – Consult with pain management specialist if > 120mg MED – Do not use Methadone – Do not prescribe opioids with other sedatives

Diving a Little Deeper Chronic Pain – sample chart note: “Chronic pain related to rheumatoid arthritis. Low pain interference under treatment. Employed and working. Low risk for opioid misuse. No aberrant behaviors. No adverse events. Continue oxycodone 5mg TID. Check UDS, PMP q 6 months. RTC 3 months with PHQ”

Diving a Little Deeper Great sections which you just have to read: – Reducing or discontinuing chronic opioids – Recognition and treatment of Opioid Use Disorder – Chronic pain during pregnancy – Chronic pain in children and adolescents – Chronic pain in older adults – Chronic pain in cancer survivors

Skimming the Surface Great tool kit:

AMDG Guideline Google: wa amdg

Summary There is a state guideline, and it works Opioids are the “great unmasker” of OUD – Aberrant behavior is a big red flag – Prescribing larger doses is NOT being compassionate There is NO safe dose of chronic opioids Opioids are sixth line therapy in chronic pain Stratify risk, measure interference with function, minimize dose

Questions/Discussion