December 02 1 Vascular mortality: Age-specific hazard ratios for 20 mmHg lower usual SBP 55 345 deaths at ages 40-89.

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Presentation transcript:

December 02 1 Vascular mortality: Age-specific hazard ratios for 20 mmHg lower usual SBP deaths at ages 40-89

December 02 2 Vascular mortality: Age-specific hazard ratios for 10 mmHg lower usual DBP (  75 mmHg) deaths at ages 

December 02 3 Stroke mortality rate in each decade of age versus usual SBP at the start of that decade Usual systolic blood pressure (mmHg) Stroke mortality (floating absolute risks & 95% CI) Age at risk:20 mmHg  SBP %  risk %  risk %  risk %  risk ( %  risk) deaths at ages

December 02 4 Stroke mortality rate in each decade of age versus usual DBP at the start of that decade Age at risk:10 mmHg  SBP %  risk %  risk %  risk %  risk ( %  risk) deaths at ages Usual diastolic blood pressure (mmHg) Stroke mortality (floating absolute risks & 95% CI)

December 02 5 Stroke mortality: Age- and sex-specific hazard ratios for 20 mmHg lower usual SBP xif.ctrl: 22-MAY :16: deaths at ages Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP

December 02 6 Stroke mortality (by sub-type): Age-specific hazard ratios for 20 mmHg lower usual SBP Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP deaths at ages 40-89

December 02 7 IHD mortality rate in each decade of age versus usual SBP at the start of that decade Age at risk20 mmHg  SBP %  risk %  risk %  risk %  risk %  risk deaths at ages Usual systolic blood pressure (mmHg) IHD mortality (floating absolute risks & 95% CI)

December 02 8 Age at risk10 mmHg  DBP %  risk %  risk %  risk %  risk %  risk IHD mortality rate in each decade of age versus usual DBP at the start of that decade deaths at ages Usual diastolic blood pressure (mmHg) IHD mortality (floating absolute risks & 95% CI)

December deaths at ages IHD mortality: Age- and sex-specific hazard ratios for 20 mmHg lower usual SBP xif.ctrl: 22-MAY :16:20.58 Age at risk Sex No. of deaths 40-49Male12020·50 (0·46-0·54) Female1200·40 (0·32-0·49) Both13220·49 (0·45-0·53) 50-59Male50270·50 (0·49-0·52) Female5670·49 (0·45-0·54) Both55940·50 (0·49-0·52) 60-69Male86090·55 (0·54-0·57) Female18410·50 (0·47-0·53) Both ·54 (0·53-0·55) 70-79Male73840·62 (0·60-0·64) Female34680·55 (0·53-0·58) Both ·60 (0·58-0·61) 80-89Male29320·69 (0·65-0·73) Female27170·64 (0·60-0·68) Both56490·67 (0·64-0·70) 0·250·350·50·71·0 Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP

December Other vascular mortality rate in each decade of age versus usual SBP at the start of that decade 9790 deaths at ages Usual systolic blood pressure (mmHg) Other vascular mortality (not stroke or IHD) (floating absolute risks & 95% CI) Age at risk:20 mmHg  SBP %  risk %  risk %  risk %  risk ( %  risk)

December Other vascular mortality rate in each decade of age versus usual DBP at the start of that decade 9790 deaths at ages Age at risk:10 mmHg  DBP %  risk %  risk %  risk %  risk ( %  risk)

December Mortality from other vascular causes (not stroke or IHD): Hazard ratios for 20 mmHg lower usual SBP deaths at ages Cause of death Mean age at death No. of deaths Heart Failure ·53 (0·48-0·59) Aortic Aneurysm ·55 (0·49-0·62) Hypertensive HD ·22 (0·20-0·25) Atherosclerosis ·48 (0·42-0·55) Sudden death ·49 (0·43-0·56) Inflammatory HD ·63 (0·53-0·75) Rheumatic HD ·74 (0·61-0·89) Other HD (excl. IHD) ·62 (0·58-0·67) Pulmonary embolism ·72 (0·60-0·87) Other circulatory ·56 (0·44-0·71) 0·250·350·50·71·0 Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP

December IHD mortality rate in each decade of age versus usual mid blood pressure at the start of that decade deaths at ages