The next generation platform for the isolation of fully human monoclonal antibodies Corporate Overview Co

Our Mission Trianni is a biotech company with the primary scientific mission of creating an optimized and highly versatile platform for isolating fully human monoclonal antibodies.

Management Team Dr. Matthias Wabl, Ph.D., Chairman & Chief Executive Officer Dr. Wabl was a cofounder and managing partner of Picobella, LLC, and a co-founder of Sagres Discovery, Inc. (now Novartis), where he served as President and as Chair, Scientific Advisory Board. He has been a member of the NIH, Small Business Innovative Research Study Section and an advisor to numerous biotechnology companies and the FDA. He is also a Professor of Microbiology and Immunology at the University of California at San Francisco (UCSF) where he has been engaged in research on the generation of antibody diversity and the basis of autoimmunity for over 20 years. He received his Ph.D. from the Max-Planck Institute in Berlin.  Dr. Zishan Haroon, M.D., Ph.D., Chief Business Officer Z Haroon MD PhD is the business and corporate development lead for Trianni. He comes with extensive experience in drug discovery and development over last two decades. In addition, he has managed business and corporate functions in both Venture and Private Equity for last 15 years. Dr. Nigel Killeen, D.Phil., Chief Scientific Officer Before moving full-time to Trianni, Dr. Killeen was Associate Professor of Microbiology and Immunology at the University of California at San Francisco (UCSF). In addition to directing a highly active research program in T lymphocyte biology, Dr. Killeen was also the director of the UCSF Transgenic and Targeted Mutagenesis facility responsible for generating genetically engineered mice for researchers in and outside the UCSF community. Dr. Killeen received his Ph.D. from Oxford University in England; he has served as a consultant to numerous biotechnology companies and has been a permanent member of the NIH Cellular and Molecular Immunology Scientific Review Panel..  Dr. Maria Wabl, M.D., Chief Financial Officer Dr. Wabl has held positions at the Max-Planck Institute in Tübingen and at the Robert-Bosch Hospital, Stuttgart, Germany. She served as fundraiser, member of the board and president of several schools in the San Francisco Bay Area. Dr. Wabl received her M.D. from the University of Tübingen, Germany.

Core Values provide the best in class antibody platform operate efficiently be responsive to our clients needs

The Trianni MouseTM Difference

The Trianni MouseTM Technology Approach Generation of Immunoglobulin H, K and λ “Acceptor Alleles” (ES cells) Design of alleles Complete repertoire of variability gene segments Deletion of V, D, and J gene segments Retention of endogenous IgH class switching DNA Mouse regulatory sequences (promoters) Ready for “recombinase-mediated cassette exchange” (RMCE) Human coding sequences Optimizations throughout Gene synthesis Modification of ES cells by RMCE and generation of mice

The Trianni MouseTM Platform

A Highly Diverse Heavy Chain Repertoire 44/44 VHs used

H CDR3 Length Distribution IgM-Sorted Naïve B cells

Heavy Chain CDR3 Compositions CDR3s of 15aa in length Human Trianni

Trianni Mice: Replete With B Cells and Antibodies

External Anti-Target 2 Abs are potent inhibitors of cytokine production

The Trianni MouseTM – Advantages

How does our partnership work?

Strategic CRO Partnerships

Business Development 2010 2011 2012 2013 2014 2015 2016 2017 Allele design and gene targeting Single Double Triple Platform assembly (breeding) and validation Licensing; platform refinements and enhancements Further enhanced alleles (more diversity, improved rearrangement efficiency…) Add-ons ,e.g., that allow for access to antigen-specific plasma cell repertoires Alleles that diversify non-antibody “scaffold” domains A novel bispecific antibody platform

TRIANNI Benefits Small company means: - easy access to our experts - lean processes (quicker time to use of our platform) - personal relationships 60 years combined industry experience Representation in key biotech locations - San Francisco, CA (West Coast, USA) - Research Triangle Park, NC (East Coast, USA) - Germany (Europe) Flexibility to create a custom partnership to match your needs Forward-thinking leadership Faster turn-around time Technical support, if needed An investment in your company. We value our partners and want you to succeed!

Contact Us 1.866.374.9314 info@trianni.com www.trianni.com