Long-term Result of Acute Type B Aortic Dissection Department of Cardiovascular Surgery, Hyogo Brain and Heart Center at Himeji, Hyogo Brain and Heart Center at Himeji, Hyogo, Japan Shunsuke Miyahara Yuya Tauchi Naoto Izawa Masaomi Fukuzumi Naoto Morimoto Hirohisa Murakami Tasuku Honda Keitaro Nakagiri Masato Yoshida Nobuhiko Mukouhara Nobuhiko Mukouhara
Background Patients with Stanford type B dissection, treated medically during the acute phase, have the risk of late aortic events, such as surgery and aortic rupture. We investigated predictors of late aortic events, focusing on the status of the false lumen at the time of onset.
Objective September 2000~May consecutive acute type B aortic dissections Surgical interventions in acute phase: 22 cases Surgery for other true aneurysms : 5 cases Follow up interval < 6 months : 4 cases <Exclusion Criteria > Acute type B aortic dissection 160 cases Age 66.1±11.6 y.o Female 37 cases (23.1%) Follow-up 44.6±25.4 mo.
Patients and Methods Acute type B aortic dissection N=160 Group T :Thrombosed false lumen without ULP N=49(30.6%) Group U :Thrombosed false lumen+ULP N=52(32.5%) Group P:Patent false lumen N=59(36.9%)
Characteristics Group TGroup UGroup P Age (y.o)69.5±8.9 n.s 70.5±7.9 p< ±15.4 p= Sex(Female%)36.7 p= n.s 16.9 p=0.020 Peripheral artery disease (%) 4.1 n.s 13.4 n.s 8.5 n.s Hyper tension (%)34.7 n.s 38.4 n.s 30.5 n.s Ischemic heart disease (%) 6.1 n.s 5.8 n.s 5.1 n.s Maximum aortic diameter at onset (mm) 36.5±5.1 p< ±6.0 p= ±6.3 p=0.028
Growth Length of Maximum Aortic Diameter ⊿Diameter(mm) Follow up (mo.) T:-0.016±0.23mm/mo. U:0.40±0.91mm/mo. P:0.44±0.49mm/mo. n.s P< P=0.0024
Freedom from Aortic Events Follow-up 33.6±20.5 mo. N Freedom from Aortic Event Months T U P P= P= P= Descending aortic replacement 10 Thoracoabdominal aortic replacement 8 Total arch replacement 5 TEVAR 3 Abdominal aortic replacement 1 Rupture 4 Other 1
Survival Follow-up 44.6±25.4mo Survival Months N % 5years 78.7% 5years 91.9% 5years T U P P=0.670 P= P= Rupture 4 SAH 3 Respiratory failure 3 Pneumonia 2 Malignancy 2 Trauma 1 Heart failure 1 Rena failure 1 Sudden death 1
Statistical Analysis of Predictors for Late Aortic Events DeBakey Ⅲ a Hyper Tension Peripheral artery diseases Ischemic Heart Disease Patent false lumen or ULPs < Max diameter at onset Aortic dilation in distal arch Female Age 95% CI*Hazard Ratio P valueUnivariate pVariables *CI: Confidence Interval Cox Proportional Hazard Analysis
Maximum Aortic Diameter at Onset Maximum Aortic Diameter at Onset (mm) 40.5mm Sensitivity for Late Aortic Events Specificity for Late Aortic Events ROC Curve P< %CI
Cases ①59y.o Female Group T Thrombosed false lumen without ULP resulted in regression. 12mo. 27mo. ②63y.o Male Group U ULP progressed to saccular aneurysm in distal arch. 6mo. ③74y.o Male Group U ULP in thrombosed false lumen recanalized into patent false lumen. 34mm 30mm 47mm59mm
Conclusions Incidence of late aortic events is higher in patients with thrombosed false lumen complicated by ULPs as well as those with patent false lumen, especially with a maximum aortic diameter >40mm at onset. Careful and regular follow-up CT examinations are needed and surgical interventions should be taken into account for these entities.