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Superior Tracking and Pushability Improved Tumor Fill Reduced Non-Target Embolization Simple Integration Superior tracking and pushability Improved tumor fill Reduced Non-Target Embolization Simple integration

Superior Tracking & Pushability Photos courtesy of Aaron Fischman, MD

Problems to be Solved Embolization with a Standard Microcatheter Tumor Stomach Liver Intestine * Injection with Standard Catheter > High Pressure Flow towards healthy tissues Embolization with a Standard Microcatheter The drug/embolic agent is injected under high arterial pressure Drug/embolic agent delivery is random and not reproducible Does not optimally fill the tumor Travels to healthy tissue via antegrade and retrograde flow

Deliver embolic agents more confidently Low Pressure Embolization (LPE) LPE represents a paradigm shift in standard drug-delivery for tumor therapy. Deliver embolic agents more confidently and with more control. LPE represents a paradigm shift in standard drug-delivery for tumor therapy. Deliver embolic agents more confidently and with more control.

Low Pressure Embolization (LPE) * > Lower Flow redirection toward tumor Embolization with a Sniper Microcatheter The balloon occludes the artery resulting in low pressure near the tumor Branch arteries are redirected and flow toward the low pressure Drug/embolic agent flows exclusively into the tumor since it has the lowest pressure Drug reaches tumor vessels Drug does not flow toward healthy tissue

Improved Tumor Fill with LPE Sniper Microcatheter with Y90 Standard Microcatheter w/ Tc-99m MAA Post-procedure SPECT Scan Post-procedure SPECT Scan Infusion with a standard high flow microcatheter results in preferential Tc-99m MAA deposition along the periphery of the tumor. Infusion with an Embolx Sniper Microcathteter yields uniform distribution of Y90 throughout entire tumor. Photos courtesy of Brian Kouri, MD

Schedule a Clinical Demonstration. Speak to an Embolx Representive to Learn More. info@embolx.com 408.990.2949 Embolx, Inc | 740 San Aleso Ave | Sunnyvale, CA 94085

Improved Tumor Fill with LPE Standard Catheter Embosphere 100-300µ Embozene 400µ Embozene 250µ InfusionType Study concluded that 2.4 X the amount of embolic agents are collected with Sniper as compared to a standard catheter. NSF Funded Animal Study

Reduced Non-target Flow with LPE Sniper® Balloon Tumor Artery Only Tumor Artery is visible, all other arteries flow toward the tumor when the Sniper® balloon is inflated Only Tumor Artery is visible, all other arteries flow toward the tumor when the Sniper® balloon is inflated Pseudo-Tumor Low Pressure Zone Right Hepatic Arteries Left Hepatic Arteries Particle Collection Tumor Artery All arteries are visible NSF Funded study conducted by at UCSD by Dr. Steve Rose, Chief of Interventional Oncology, UCSD Medical Center

Simple Integration High performance with comparable pricing to standard microcatheters Compatible with 5Fr diagnostic/guide catheter Easy to use Requires no additional accessories High performance with comparable pricing to standard microcatheters Compatible with 5Fr diagnostic/guide catheter Easy to use Requires no additional accessories

What Experts are Saying: "Bottom line, fixed temporary occlusion balloons and dynamic anti-reflux devices for transarterial embolization of liver tumors appear to simultaneously improve both safety and efficacy.” Steven C. Rose, MD FSIR Director of Interventional Oncology University of California, San Diego, CA

What Experts are Saying: "Manipulating blood pressure and flow to improve the tumor-killing effects of embolization therapies is a promising new technique. Using an occlusion balloon catheter has the potential of not only improving outcomes, but also simplifying the treatment technique to make this option available to more patients and doctors." Daniel Sze, MD PhD | Professor, Interventional Radiology Stanford University Medical Center Daniel Sze, MD PhD | Professor, Interventional Radiology Stanford University Medical Center

Schedule a Clinical Demonstration. Speak to an Embolx Representive to Learn More. info@embolx.com 408.990.2949 Embolx, Inc | 740 San Aleso Ave | Sunnyvale, CA 94085