Pentose Phosphate Pathway (PPP)

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Presentation transcript:

Pentose Phosphate Pathway (PPP) بيوشيمي عمومي گروه علوم دامي دانشکده کشاورزي دانشگاه ياسوج دکتر مختار خواجوی Pentose Phosphate Pathway (PPP)

PPP Shunt glycogen PPP The pentose phosphate pathway (PPP) is the source of ribose (deoxyribose), and NADPH. NADPH is required for biosynthesis.

Pentose Phosphate Pathway Shunt Synthesize 3 pentose phosphates Ribulose 5-P Xylulose 5-P Ribose 5-P (DNA/RNA) And NADPH (for the reduction of RNA to DNA) Or NADPH and glycolytic intermediates Rapidly dividing cells need lots of NADPH and DNA High PPP activity

The Oxidation Stage of PPP Allosteric - NADPH Major reg step Loss of Carbon

The Non-Oxidation Stage of PPP All equilibruim rxns When cells need lot of NADPH and nucleotides - ribulose 5-phosphate  ribose 5-phosphate - end of pathway

The Non-Oxidation Stage of PPP Convert 5C sugars into glycolytic intermediates Can be used in glycolysis of Gluconeogenesis

Pentose Phosphate Pathway Thru PPP 3 Glc-6-P + 6 NADP+ + 3 H2O  2 Fru-6-P + G3P + 6 NADPH + 3 CO2 Allow sub regeneration via PPP and glyconeogenesis Recycle 6C sugar 6 ribulose 5-P 5 Glc 5-P 6 Glc-6-P + 12 NADP+  5 Glc-6-P + 12 NADPH + 6 CO2 + Pi Can be metabolized in Glycolysis or Glcneogenesis