SECCN/SPACeR Critical Care Conference Introduction to the NIHR Research Design Service Research Design Service- South East Dr Bernadette Egan University of Surrey 02/06/2015

The NIHR Health Research System Research Research Projects & Programmes Research Governance Systems Research Information Systems Patients & Public Universities Investigators & Senior Investigators Associates Trainees Research Design Service & CTUs NHS Trusts Clinical Research Networks Clinical Research Facilities, Centres & Units Infrastructure Systems Faculty Research units & Schools 02/06/2015

Research Design Service NIHR Remit Support of applied health research Research has a clear potential to benefit patients and the public within 3-5 years Involvement of patients and public in research design The research can involve patients, samples or data from patients, people who are not patients, populations, health technology assessment and health services research NIHR does not support basic research or work involving animals and/or animal tissue

Research Design Service “To increase the number and proportion of high quality applications for funding …” 02/06/2015

RDS South East 02/06/2015

Research Design Service RDS team at Surrey Dr Bernadette Egan: Academic Lead/Research Adviser Dr Jo Leftwich: Research Adviser (currently on maternity leave) Professor Heather Gage: Health Economist/Research Adviser Dr Dan Jackson: Health Economist Mr Jake Jordan: Health Economist Dr Jeewaka Mendis: Medical Statistician Mr Peter Williams: Medical Statistician Miss Kay Stephenson: Patient & public involvement & general support

Research Ideas How can the RDS help? Research Question

Appropriate funding stream Literature Research Question Peer-reviewed journals Grey literature Registered trials database Scope How can the RDS help?

Appropriate funding stream Literature Study Design Research Question Peer-reviewed journals Grey literature Registered trials database Scope Cohort, case-control, RCT, ethnographic, interview How can the RDS help?

Appropriate funding stream Literature Study Design Research Question Peer-reviewed journals Grey literature Registered trials database Scope Feasibility Cohort, case-control, RCT, ethnographic, interview Cost issues Recruitment Appropriate time scale? How can the RDS help?

Research Design Service What to cost & who will pay? Costs of R&D in the NHS are split into 3 categories; Research Costs NHS Support Costs (service support) Treatment Costs

Appropriate funding stream Literature Study Design Research Question Peer-reviewed journals Grey literature Registered trials database Scope Involvement of patients and public Feasibility Cohort, case-control, RCT, ethnographic, interview Cost issues Recruitment Appropriate time scale? Meaningful & appropriate How can the RDS help?

Research Design Service PPI INVOLVE Involvement Cost Calculator cost-calculator/ “Were patients and the public actively involved in either identifying the research topic/prioritising the research question and/or preparing this application? ”

Appropriate funding stream Literature Study Design Research team Research Question Peer-reviewed journals Grey literature Registered trials database Scope Multidisciplinary team Involvement of patients and public Feasibility Cohort, case-control, RCT, ethnographic, interview Cost issues Recruitment Appropriate time scale? Meaningful & appropriate How can the RDS help? 07/05/2015

Research Design Service Highlight the Skill mix Relevant skills and experience in the team? Adequate staffing for all elements of the project? Appropriate project management? ‘Sell’ previous experience of the team Limited experience of running research?

Appropriate funding stream Literature Study Design Research team Ethical considerations Research Question Peer-reviewed journals Grey literature Registered trials database Consent Scope Multidisciplinary team Involvement of patients and public Feasibility Cohort, case-control, RCT, ethnographic, interview Cost issues Recruitment Appropriate time scale? Meaningful & appropriate How can the RDS help? 07/05/2015

Impact Appropriate funding stream Literature Study Design Research team Ethical considerations Research Question Peer-reviewed journals Grey literature Registered trials database Consent Scope Multidisciplinary team Involvement of patients and public Feasibility Cohort, case-control, RCT, ethnographic, interview Cost issues Recruitment Appropriate time scale? Meaningful & appropriate Benefit to NHS and patients How can the RDS help? Research Proposal Slides 8-20 courtesy of Dr Wendy Baird, RDSYH

Research Design Service Who can access the RDS? NHS staff applying for funding for research Academics working with (or planning to work with) NHS staff on a research funding application NIHR Fellowship applicants Do not have to be applying for NIHR funding (any non-commercial funding in applied health and social care )

Research Design Service NIHR Programmes Efficacy and Mechanism Evaluation (EME) Health Services & Delivery Research (HS&DR) Health Technology Assessment (HTA) Invention for innovation (i4i) Public Health Research (PHR) Programme Grants for Applied Research (PGfAR) Programme Development Grants (PDG) Research for Patient Benefit (RfPB) ( PGfAR, PDG and RfPB funding must be held by an NHS institution)

Research Design Service Research for Patient Benefit Regional programme Any area of research leading to patient benefit Up to £350k for 3 years Funding must be awarded to an NHS Trust, so an NHS partner needed Often funds feasibility projects (£250K)

Research Design Service Health Technology Assessment Both commissioned and investigator-led calls Evaluation of interventions, often involving a clinical trial Primary and secondary research on the effectiveness of new technology -‘Technology’ interpreted widely Feasibility studies & pilot studies now eligible

Research Design Service Health Technology Assessment Typical HTA randomised control trial: Multidisciplinary and multi-centre (requires CTU) Effectiveness and cost-effectiveness (requires health economics) Median number of patients = 700 (Range of 15 to 100,000 across current projects) Average duration 4-5 years Average cost over £1.5 million

Research Design Service Health Services and Delivery Research Research to improve the quality, effectiveness and accessibility of the NHS, including evaluations of how the NHS might improve delivery of services. Considers both primary & secondary research Pilot and feasibility studies considered Relevant areas of social care as well as health are considered Funding generally over £400K

Research Design Service Programme Grants for Applied Research Prestigious awards directed towards leading researchers who can demonstrate an impressive track-record of achievement in applied health research Up to £2m over 5 years Awarded to an NHS Trust Each programme funds a series of related projects, which form a coherent theme in an area of priority or need for the NHS

Research Design Service Programme Grants for Applied Research Emphasis is on delivering research findings that will have practical application for the benefit of patients, typically through improved health care or better health care delivery Balanced teams of leading researchers, from the NHS and academia Have a multidisciplinary approach to research (including clinical, health economics, statistics, qualitative and behavioural sciences) Involvement of multiple sites essential

NIHRTCC Research Career Pathways Nurses, Midwives, Allied Health Professionals Clinical Academic Training NIHR/HEE Masters in Clinical Research NIHR/HEE Clinical Doctoral Research Fellowship NIHR/HEE Senior Clinical Lecturership NIHR/HEE Clinical Lectureship Methodologists Research Methods Programme NIHR Research Methods Fellowship and Internship NIHR Masters Studentship in Health Economics or Medical Statistics Level of Award Undergraduate Chair Senior/ Pre- Chair Post Doctoral (early to senior) Doctoral Pre Doctoral Doctors and Dentists NIHR IntegningProgramme NIHR Clinician Scientist Award NIHR In-Practice Fellowship NIHR Academic Clinical Fellowship Healthcare Scientists Healthcare Science Programme NIHR/HEE Health Care Science Doctoral Fellowship NIHR/HEE Health Care Science Post-Doctoral Fellowship NIHR/HEE Senior Clinical Lecturership NIHR Doctoral Research Fellowship NIHR Post- Doctoral Fellowship NIHR Career Development Fellowship NIHR Senior Research Fellowship NIHR Research Professorship NIHR Transitional Research Fellowship NIHR Clinical Trials Fellowship NIHR Knowledge Mobilisation Research Fellowship All Professions NIHR Fellowships, Professorships and Other Awards NIHR Clinical Lectureship

SECCN/SPACeR Critical Care Conference 07/05/2015