Human Genetic Diversity By Nataliya Prokhnevska Stanley David Alexander Reese Ryan Haddock JuneHee Chang.

Slides:



Advertisements
Similar presentations
Admixture in Horse Breeds Illustrated from Single Nucleotide Polymorphism Data César Torres, Yaniv Brandvain University of Minnesota, Department of Plant.
Advertisements

MStruct: Structure under mutations Suyash Shringarpure and Eric Xing Carnegie Mellon University mStruct: Inference of population structure in the presence.
Biology and Bioinformatics Gabor T. Marth Department of Biology, Boston College BI820 – Seminar in Quantitative and Computational Problems.
A review of polygenic inheritance. Global Patterns of Human Variation Can be examined genetically Can be examined phenotypically Are phenotypic differences.
The Emperor’s New Clothes: Biomedical Research and the Social Construction of Race Summer Public Health Videoconference on Minority Health, June 18 th.
Dispersal models Continuous populations Isolation-by-distance Discrete populations Stepping-stone Island model.
Evolutionary Genome Biology Gabor T. Marth, D.Sc. Department of Biology, Boston College Medical Genomics Course – Debrecen, Hungary, May 2006.
Human Migrations Saeed Hassanpour Spring Introduction Population Genetics Co-evolution of genes with language and cultural. Human evolution: genetics,
BI420 – Course information Web site: Instructor: Gabor Marth Teaching.
Global Patterns of Human Variation. Human Variation Can be examined genetically Can be examined phenotypically Are phenotypic differences concordant with.
Gene Frequency and Natural Selection Team Brainstormers (BS) Spring Feb 2015.
Scientific FieldsScientific Fields  Different fields of science have contributed evidence for the theory of evolution  Anatomy  Embryology  Biochemistry.
Exploring Current DNA Research of Longhorn Cattle.
Evolution and Human Behavior Grades: 9-12 C.Batterman.
Population Dynamics Humans and malaria. Science (2010), v.328:841.
The Rise of Genomics AP Biology Fall The Human Genome Project  With the invention of PCR and automated sequencing, scientists argued for the sequencing.
Fossil Record & Homologies  Scientists have used the fossil record to construct a history of life on Earth. This is only a theory Fossil record is not.
Chapter 24: Molecular and Genomic Evolution CHAPTER 24 Molecular and Genomic Evolution.
26.1 Organisms Evolve Through Genetic Change Occurring Within Populations. “Nothing in Biology makes sense except in the light of Evolution” –Theodosius.
AdvancedBioinformatics Biostatistics & Medical Informatics 776 Computer Sciences 776 Spring 2002 Mark Craven Dept. of Biostatistics & Medical Informatics.
Announcements Urban Forestry data and photos due next week after the break. Reading. Writing assignment due Oct 18. Choose one of the characteristics out.
BIOLOGY WEEK 26. MUST DO Species are distinct natural entities, with a clear definition, that can be easily recognized by anyone. many bacteria reproduce.
Chapter 22 Descent with Modification: A Darwinian View.
Evolutionary Genome Biology Gabor T. Marth, D.Sc. Department of Biology, Boston College
Chapter 1 Principles of Life
Evolutionary Medicine 2015 UNM Evolutionary Medicine Joe Alcock MD MS Department of Emergency Medicine Adjunct, Dept. Biology.
Chapter 1 Principles of Life. All organisms Are composed of a common set of chemical components. Genetic information that uses a nearly universal code.
Higher Human Biology Unit 1 Human Cells KEY AREA 5: Human Genomics.
Inferences on human demographic history using computational Population Genetic models Gabor T. Marth Department of Biology Boston College Chestnut Hill,
Lecture 24: Human Origins and Signatures of Selection April 11, 2014.
Journal Club Presentation BIOL368/F16: Bioinformatics Laboratory
Population Dynamics Humans and malaria.
BrGSP: the Brassica 'A' genome sequencing project
The Short Sightedness and its Pitfalls
Schedule Cultural connection Introduction to evolution
Overview Bioinformatics: Analyzing biological data using statistics, math modeling, and computer science BLAST = Basic Local Alignment Search Tool Input.
Genome organization and Bioinformatics
KEY CONCEPT Entire genomes are sequenced, studied, and compared.
STATISTICAL GENETICIST DR. JANET SINSHEIMER
Human Genetics: Questions, Challenges, and the Future
Genome Evolution: Horizontal Movements in the Fungi
Classification Evolution Unit.
Evidence and Phylogenetic trees
KEY CONCEPT Entire genomes are sequenced, studied, and compared.
Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors  Michael Dannemann, Aida M.
Genome Evolution: Horizontal Movements in the Fungi
Volume 26, Issue 24, Pages (December 2016)
Incorporating changing population size into the coalescent
Alessia Ranciaro, Michael C. Campbell, Jibril B
Gene Discovery for Complex Traits: Lessons from Africa
The Platypus Genome Unraveled
Volume 150, Issue 3, Pages (August 2012)
Study of the genetic relationship and diversity patterns in the Azores based on 15 STR markers  C.C. Branco, M. São Bento, C.T. Gomes, R. Cabral, A.M.
The Predecessors Within
by Benjamin Vernot, Serena Tucci, Janet Kelso, Joshua G
Unit Genomic sequencing
Approximation Algorithms for the Selection of Robust Tag SNPs
Inferring Tumor Phylogenies from Multi-region Sequencing
Identifying Darwinian Selection Acting on Different Human APOL1 Variants among Diverse African Populations  Wen-Ya Ko, Prianka Rajan, Felicia Gomez, Laura.
Introduction to Bioinformatics
Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation  Mario Leutert,
Genomic phylogeny reveals the long-term coexistence of diverse clades.
Complex History of Admixture between Modern Humans and Neandertals
Evidence for Human Variation and Adaption
Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors  Michael Dannemann, Aida M.
Rafal S. Sobota, Catherine M. Stein, Nuri Kodaman, Laura B
Genomics in Africa: Avoiding Past Pitfalls
The Technology and Biology of Single-Cell RNA Sequencing
Chloe Arwood, Ryan Jun and Yue Wen
Presentation transcript:

Human Genetic Diversity By Nataliya Prokhnevska Stanley David Alexander Reese Ryan Haddock JuneHee Chang

Introduction  Phylogenetic trees are a way of organizing data that show evolutionary patterns and relationships

Introduction  Scientists use machines called sequencers to sequence entire genomes from collected tissue samples. They use this data to study human genetics and make phylogenetic trees.  A project called 1000 genomes was started by researchers to establish a phylogenetic tree of the entire human race. African-American populations were understudied, so researchers decided to look into their genome.

Data  This is the allele frequencies that were collected from the sequenced genomes of each of the different populations of hunter-gatherers Lachance et al. 2012

Results

Discussion  By finding the differences in the sequenced genomes they were able to produce a phylogenetic tree where the different populations of African hunter-gatherers fit into. Lachance et al. 2012

Conclusion  Phylogenetic trees use genetics in order to map out how populations change over time and how they are related to each other.

Sources 1. Joseph Lachance, Benjamin Vernot, Clara C. Elbers, Bart Ferwerda, Alain Froment, Jean-Marie Bodo, Godfrey Lema, Wenqing Fu, Thomas B. Nyambo, Timothy R. Rebbeck, Kun Zhang, Joshua M. Akey, Sarah A. Tishkoff, Evolutionary History and Adaptation from High-Coverage Whole-Genome Sequences of Diverse African Hunter-Gatherers, Cell, Volume 150, Issue 3, 3 August 2012, Pages Cell Press (2012, July 26). Whole-genome sequencing of African hunter-gatherers reveals human genetic diversity. ScienceDaily. 3. Freeman, Scott. "27." Biological Science. 4th ed. Boston: Benjamin Cummings, Print. 4. "Home | 1000 Genomes." Home | 1000 Genomes. N.p., n.d. Web. 8 Sept