Using a construction site as an analogy for how proteins effect phenotype Mutation Unit: The Cellular Construction Zone Scripps Classroom Connection

Engage Overview ● Hypothesizing: ● What are proteins? ● What jobs do proteins have in the cell? ● How do protein’s different jobs affect a cell’s phenotype? ● Questioning: ● What do you think of when I say mutant? ● What causes mutants to look different? ● What are three main concepts you learned from the video? ● Multimedia: ● Brain pop video on DNA/ genes Scripps Classroom Connection

Hypothesize 1. What are proteins? 2. What jobs do proteins have in the cell? 3. How do protein’s different jobs effect a cell’s phenotype? Scripps Classroom Connection

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What do you think of when I say mutant? Write a sentence and/or draw a picture on your white board. Share it with your table. Scripps Classroom Connection

What causes mutants to look different? Discuss as a table, then share out your ideas to the class. Scripps Classroom Connection

What makes organisms look the way they do? Scripps Classroom Connection

Explore overview ● Genetic elements and their relationships ● Matching activity ● Students match images of genetic elements with names ● Necessary materials ● 1.DNA relationships worksheet.pdf ● Cellular Construction Zone: Matching activity ● Matching activity ● Uses a construction site analogy ● Students match “protein” functions with images ● Necessary materials ● 1. Construction site matching. docx Scripps Classroom Connection

Genetic elements and their relationships matching activity Scripps Classroom Connection Base Pairs Parts of DNA that can be arranged in a code that determines a trait

Base Pairs parts of DNA that can be arranged in a code that determines a trait Scripps Classroom Connection A. E. D. C. B.

Chromosomes are made of condensed DNA Gene Scripps Classroom Connection

DNA contains pairs of bases Scripps Classroom Connection

Genes determine phenotype Tail Color Genes ? ? ? Proteins Scripps Classroom Connection

What is a protein? Compounds made by organism’ s bodies Involved in almost everything that happens in living organisms Proteins are involved in determining phenotype Genes Proteins Lots of different functions Phenotype Scripps Classroom Connection

Single celled organisms have phenotypes too Scripps Classroom Connection

Cellular construction zone overview ● Activity: Matching ● Construction workers and their jobs are used to represent proteins and their roles in a cell ● Matching key ● House: A cell ● Frame of the house: Protein that determines cell shape ● Worker carrying board up ladder: Protein that transports the cell’s building blocks ● Worker building the brick wall: Protein that builds cell wall ● Worker with the megaphone: Protein that starts and stops processes Scripps Classroom Connection

A.Protein that determines the cell shape B. Protein that transports the cell’s building blocks C. Protein that builds the cell wall D. Protein that starts and stops processes E. A cell Scripps Classroom Connection

A.Protein that determines the cell shape B. Protein that transports the cell’s building blocks C. Protein that builds the cell wall D. Protein that starts and stops processes E. A cell Scripps Classroom Connection

E. A cell D. Protein that starts and stops processes B. Protein that transports the cell’s building blocks C. Protein that builds the cell wall A. Protein that determines the cell shape Scripps Classroom Connection

Vocabulary: ● Protein: Compounds made by organisms that are involved in almost every aspect of what happens in living organisms. ● Function: What something does, or its job. Scripps Classroom Connection

Explain Overview ● Analysis questions, to be discussed at tables and recorded in notebooks ● What would happen to the building if the workers did their jobs differently? ● What is an example of a way a worker would change what they were doing? ● How would this change the way the building looked? ● How does a construction site represent a cell with proteins? ● What causes a mutant to look different? Scripps Classroom Connection

What would happen to the building if the workers did their jobs differently? ? ?

Scripps Classroom Connection What is an example of a way a worker would change what they were doing? ? ?

Scripps Classroom Connection How would this change the way the building looked? ? ?

Scripps Classroom Connection How does a construction site represent a cell with proteins? ? ?

Scripps Classroom Connection How does a construction site represent a cell with proteins? o The worker who builds the walls on the house is like a that builds in the cell. o The frame of the house is like the of the cell.

What causes a mutant to look different? Scripps Classroom Connection