VUOS Photo tour PARTNER FOR COOPERATION

2 22VUOS – PARTNER FOR COOPERATION Buildings

3 33VUOS – PARTNER FOR COOPERATION Buildings 215 employess Skilled – 25 % Secondary – 30% University degree – 36% Ph.D. degree – 9%

4 44 VUOS – PARTNER FOR COOPERATION Laboratories Analytical methods NMR Spectrometry Mass Spectrometry (LC/GC-MS) ICP-AES IR Spectrometry Chromatography (HPLC, GC) UV-VIS

5 55VUOS – PARTNER FOR COOPERATION Laboratories Toxicological tests In vivo and in vitro tests according to the OECD or EU methods: Acute toxicity Skin and Eye irritation Sensibilisation Repeated dose toxicity Reproductive toxicity Carcinogenicity Mutagenicity

6 66VUOS – PARTNER FOR COOPERATION Kilolab – Multipurpose chemistry 20x glass reactors, 100 l each 6x glass lined reactors (200–1 500 l) 2x evaporators 50 l / h 4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity

7 77VUOS – PARTNER FOR COOPERATION Low temperature production line 1 x glass reactor 50 l cooled down to – 80 ˚C 1x glasslined reactor for NaH reactions (250 l) 3x glass reactors 100l for RLi, Grignard reactions

8 88VUOS – PARTNER FOR COOPERATION Low temperature production line Reactors up to 630 l cooled down to – 80 ˚C 1x glass-lined reactor for NaH reactions (250 l) 3x glass reactors 100 l cooled down to – 40°C

9 99VUOS – PARTNER FOR COOPERATION Low temperature production line

10 VUOS – PARTNER FOR COOPERATION Phosgenation Reactors up to l 2x High performance rectification columns Laboratory phosgenation units from 1 to 30 l

11 VUOS – PARTNER FOR COOPERATION Phosgenation

12 VUOS – PARTNER FOR COOPERATION Hydrogenation 3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200 ˚C, Hastelloy C clad 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel 1x autoclave l, 10 bar, 140 ˚C, stainless steel many autoclaves up to 10 l

13 VUOS – PARTNER FOR COOPERATION Hydrogenation

14 VUOS – PARTNER FOR COOPERATION Hydrogenation

15 VUOS – PARTNER FOR COOPERATION Filtration Sufficient filtration capacity (nutsches, centrifuges)

16 VUOS – PARTNER FOR COOPERATION Filtration

17 VUOS – PARTNER FOR COOPERATION Centrifuge

18 VUOS – PARTNER FOR COOPERATION Venulet

19 VUOS – PARTNER FOR COOPERATION Reactors 52x glass lined reactors, total vol l (500 – l) 16x stainless steel reactors, total vol l (1 000–6 000 l) 8x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled

20 VUOS – PARTNER FOR COOPERATION Reactors

21 VUOS – PARTNER FOR COOPERATION Reactors

22 VUOS - PARTNER FOR COOPERATION Glass-lined vessels 400 and 630 l Stainless steel vessels 400 and 630 l Filtration, Centrifuging and Drying GMP Production Line certified since 2015 Production of API Starting materials and advanced intermediates Controlled finalization of final products

23 VUOS - PARTNER FOR COOPERATION GMP Production Line certified since 2015

24 VUOS – PARTNER FOR COOPERATION Warehouse

25 VUOS – PARTNER FOR COOPERATION Warehouse

26 VUOS – PARTNER FOR COOPERATION Warehouse

27 Výzkumný ústav organických syntéz a.s. Rybitví č.p. 296, Rybitví, Czech Republic