NEW FACULTY ORIENTATION Introduction to the UMSOM Research Enterprise Richard N. Pierson III, MD, FACS Senior Associate Dean for Academic Affairs Interim Director for Research Affairs November 6, 2013

University of Maryland School of Medicine SOM Research Faculty Funding Total Faculty Research Productivity National Avg. $315K/PI UMB Avg. $500K/PI; 18 th most productive nationally AAMC National Ranking 7 th among 76 public medical schools 23 rd among 143 public and private medical schools Total Grants and Contracts Expenditures

University of Maryland School of Medicine NIH : Funding Profile of Current SOM Research Faculty PROGRAM PROJECTS MENTAL RETARDATION CENTER GRANTS (5) AGING (Pepper Center) POLYCYSTIC KIDNEY DISEASE NCI DESIGNATED CANCER CENTER NUTRITION OBESITY RESEARCH GENOMICS OF PAIN

University of Maryland School of Medicine NIH : Funding Profile of Current SOM Research Faculty TRAINING GRANTS (14) TOXICOLOGY/EPIDEMIOLOGY INTEGRATIVE MEMBRANE BIOLOGY IMMUNITY AND INFECTION VASCULAR BIOLOGY CARDIOVASCULAR CELL BIOLOGY CANCER BIOLOGY CELLULAR INTEGRATIVE NEUROSCIENCE SIGNALING PATHWAYS IN INNATE IMMUNITY MUSCLE BIOLOGY

University of Maryland School of Medicine NIH : Funding Profile of Current SOM Research Faculty TRAINING GRANTS (14) (CLINICAL FIELDS) GASTROENTEROLOGY SCHIZOPHRENIA RESEARCH MEDICAL SCIENTIST TRAINING (MD/PhD) VACCINOLOGY GERONTOLOGY/EXERCISE PHYSIOLOGY EPIDEMIOLOGY OF AGING

University of Maryland School of Medicine SOM Organized Research Centers Health Policy & Health Services Research Integrative Medicine (CIM) Health-Related & Imaging Bioinform. (CHIB) Research on Aging (Pepper) Shock, Trauma and Anesthesiology (STAR) Stem Cell Biology & Regenerative Medicine Vaccine Development (CVD) Vascular and Inflammatory Diseases (CVID)

University of Maryland School of Medicine SOM Programs Comparative Medicine (Vet. Resources) Genetics and Genomic Medicine Minority Health and Health Disparities Neuroscience Oncology Personalized & Genomic Medicine Trauma

University of Maryland School of Medicine UM Institute of Human Virology (IHV) Robert Gallo, MD Director, Institute of Human Virology Professor, Department of Medicine Dr. Claire Fraser D irector, Institute for Genome Sciences Professor, Department of Medicine UM Institute for Genome Sciences (IGS) SOM Institutes* * Excludes the newly established Clinical and Translation Science Institute (CTSI)

University of Maryland School of Medicine Efforts to Enhance Research Opportunities Office of Research Career Development Target Audiences: –New Faculty (junior principle investigators) –Post-doctoral research scientists First Priority - to develop workshops, classes and consultation services focusing on: - Writing a Competitive Grant Application - Revising a Grant Application - Individual mentoring - Identifying Funding Opportunities Wendy Sanders, Stacy Small

University of Maryland School of Medicine Basic and Clinical Resources Network  NICHD Brain/Tissue Bank for Developmental Disorders  Pathology Biorepository and Research Core  Maryland Psychiatric Research Center’s Brain Bank  Histology Core  Biostatistics Shared Resource (Epi/PH)  Clinical Translational Research Informatics Center (CTRIC)  Informatics Resource Center  Pharmaceutical Research Computing  BIORESCO (Biomedical Research Supply Core)

University of Maryland School of Medicine Dept of Epidemiology/PH –Statistics, biocomputation, study design, mock review – (Jay Magaziner) IRB (HRPO) - ( Susan Buskirk ) –CICERO: assistance with submission Electronic systems submission -- –COEUS grant submissions review – (ORD) –Conflict of Interest review- (Nancy Lowitt) –IACUC protocol review ( Peiser/Sacci ) Planned CTSI (GCRC, K12) (Davis/Shuldiner) Support for Enhanced Clinical Research

University of Maryland School of Medicine Genomics and other “omics” cores Small Animal Physiology core Vet services and facilities review Animal Imaging Center (6 HH ) –7T MRI, CT/PET, Ultrasound; TEM/SEM Confocal microscopy (6 HH) Flow Cytometry, sorting (7 BRB) GLP capability (Vet Med) GCP (Personalized Medicine) (7BRB) Dean’s office personnel and support for complex grant preparation, submission and management Seed funding and Bridge funding Infrastructure to Enhance Research Environment

University of Maryland School of Medicine Available Core Facilities and Shared Resources Imaging Network Confocal Microscopy Electron Microscope Animal Imaging MRI Research Imaging Neuroimaging Imaging Network Confocal Microscopy Electron Microscope Animal Imaging MRI Research Imaging Neuroimaging Clinical Resources Network Pathology Biorepository Brain & Tissue Banks Cytokine & Hormone Immunoassay Core Flow Cytometry Clinical Resources Network Pathology Biorepository Brain & Tissue Banks Cytokine & Hormone Immunoassay Core Flow Cytometry Model Development Network Novel Model Systems Development Veterinary Services Translational Core Lab Small Animal Physiology Core Model Development Network Novel Model Systems Development Veterinary Services Translational Core Lab Small Animal Physiology Core Drug Development Network Pharmacokinetics/Biopharmaceutics Lab Industrial Pharmaceutics Lab Center for Nanomedicine and Cellular Delivery Computer-Aided Drug Design (CADD) High Throughput Screening Core Drug Development Network Pharmacokinetics/Biopharmaceutics Lab Industrial Pharmaceutics Lab Center for Nanomedicine and Cellular Delivery Computer-Aided Drug Design (CADD) High Throughput Screening Core Genomics Network Biopolymer/Genomics Core Genomics Resource Center Biochemical Genetics Lab Cytogenetics Lab Translational Genetics Core Genomics Network Biopolymer/Genomics Core Genomics Resource Center Biochemical Genetics Lab Cytogenetics Lab Translational Genetics Core Structural Biology Network NMR X-Ray Crystallography Proteomics/Mass Spec. Biacore Edman Sequencing Structural Biology Network NMR X-Ray Crystallography Proteomics/Mass Spec. Biacore Edman Sequencing Bioengineering & Biorobotics Network UMCP Bioengineering & Biorobotics Network UMCP

University of Maryland School of Medicine Core FacilityDirector Confocal MicroscopyTom Blanpied Electron MicroscopyRu-ching Hsia Animal ImagingRao Gullapalli MRI Research ImagingRao Gullapalli NeuroimagingWill Carpenter NMRDavid Weber X-Ray CrystallographyEric Toth BiacoreRobert Bloch Edman Sequencing/Protein AnalysisBrian Hampton Pathology BiorepositoryOlga Ioffe Developmental Brain BankRon Zielke Cytokine LabJeff Hasday Flow Cytometry (CVD)Marcelo Sztein Flow Cytometry (UMGCC)Ferenc Livak High Throughput Screening CorePaul Wilder Veterinary ResourcesLouis Detolla Translational Core LabRena Lapidus Small Animal Physiology CoreLing Chen Transgenic/Novel Model SystemsValerie Stewart Biopolymer/Genomics CoreNick Ambulos Genomics Resource CenterLisa Sadzewicz Biochemical Genetics LabMimi Blitzer Cytogenetics LabYi Ning Translational Genomics LabNick Ambulos Imaging Structural Biology Clinical Resources Drug Development Model Development Genomics

University of Maryland School of Medicine Structural Biology Network  NMR Center (Center for Biomolecular Therapeutics)  X-ray Crystallography Core  Mass Spectrometry Core  Proteomics Core (SOM, SOP)  Edman Sequencing and Protein Analysis Core  BiaCore Core Facility  Protein Production and Purification

University of Maryland School of Medicine Drug Development Network  Pharmacokinetics Biopharmaceutical Laboratory  Industrial Pharmaceutics Laboratory  Clinical Pharmacology Unit  Center for Nanomedicine and Cellular Delivery  Computer Aided Drug Design  High-throughput Screening Core  Center for Biomolecular Therapeutics (SOM at Shady Grove)

University of Maryland School of Medicine NIH Construction Grant Space Renovations: BRB-7, HH and HSF1-6 Renovations to BRB-7 provides new space for research core facilities (Flow Cytometry, Mass Spectrometry, Biopolymer, Transgenic), Clinical Cytogeneics, and a CLIA-certified Personalized Genomics core with robotic sample archive. Renovations to the 6 floor of HSF1 and HH provide renovated research space for consolidated imaging cores (Electron Microscopy, Confocal Microscopy, in vivo animal imaging, MRI, PET-CT, ultrasound). Completed September, 2013 –Ribbon-cutting 11/22/13 (Festival of Science).

University of Maryland School of Medicine NIH Core Renovation and Consolidation Grant BRB-7 Renovations to BRB-7 include an open lab design for the north side (top), which will physically consolidate a number of existing core facilities such as Biopolymer, Transgenic, translational Lab, BIACore, Proteomics, and others. The south side (bottom), will allow development of new resources that will specifically support clinical and translational research. Estimated date for completion: August, 2012.

University of Maryland School of Medicine NIH Core Renovation and Consolidation Grant BRB-6 Proposed renovations to BRB-6 will result in a comprehensive imaging suite between BRB and Howard Hall 6 th floors. This will include Electron Microscopy, Confocal Microscopy and whole animal imaging (MRI, PET/CT).

University of Maryland School of Medicine Research Environment - Space Management Existing Space allocation: annual reassessments for productivity Dry lab space: lease commercial building space Wet lab space: renovate and repurpose labs New HSF III (2018) – 178,000 NASF: Planning and Design started Building and Leasing: UMB Biopark – Ongoing development potential

A new Institutional collaboration to maximize research and expertise across campuses for the benefit of the faculty, state and citizens of Maryland. UMB / UMCP Collaboration M-Power Maryland

UMB & UMCP Funding and Joint Seed Programs FY2012 Total Grant & Contract Funding UMB – approx. $ 500 million UMCP – approx. $ 500 million Significant Economic Impact for the State UMB-UMCP Joint Seed Program FY – Funded 48 grants totaling $3.8M New SEED programs in : CBT/IBBR ($300K), CTSI ($150K), UMB/UMBC ($275K) Important Resource for future federal and non- federal research proposals

University of Maryland School of Medicine Closing Seek out the tools to help you advance Manage the space available wisely Use the expertise and collaborative spirit of the faculty to help guide you Take advantage of all of these highly productive and leveraged resources for success Communicate with mentors and peers often Enjoy your experience in SOM and use your time well to contribute to the community