ULTRA TRACES ANALYSES AQUITAINE Technological Centre for trace element analyses Hugues PAUCOT

UT2A : Technological Centre managed by ADERA Association Created in January 1999 thanks to Aquitaine region and FEDER funds Special Partnership with LCABIE / IPREM (UMR 5254) Fields of expertise and markets –Trace element analyses –Speciation –Bio-molecule determination –Chemical process characterisation –Training and consulting Description

Why UT2A ? The technological trends in the sector of the analytical chemistry of trace elements (As, Cr, Hg, Se, S…) require a rapid adaptation of the operators and the methods –UT2A supports analytical laboratories, laboratories of control, and R&D departments in their initiative of development of their analytical potential UT2A Active partner for the applications in analytical chemistry –Applications of new concepts and new methodologies

UT2A positioning IPREM Know how in state- of-the-art analytical chemistry Support of highly specific instrumentation Analytical methods development Companies/ Laboratories Expressions of needs in specific analyses Access to technologies directly stemming from the research Initiative towards the innovation Analytical subcontracting Relation Research - Industry Know How diffusion Participation in the valuation of the research, and in the distribution of the know-how

UT2A: A technological centre 11 permanents staff (5 engineers, 2 assistants-engineers, 2 technicians, 2 administrative staff) More than 500 Analytical contracts per year 400 m² of laboratories equipped with : – 1 clean lab – 2 ICP-MS + hyphenation of GC and HPLC – 1 Ionic Chromatographic system – 1 Polarography system – Sample preparation (micro-waves, heating plates, crusher, steam, etc…)

Available analytical techniques in partnership with LCABIE / IPREM ICP-MS (10 available instruments) of whom 1 High Resolution and 1 multi-collector –GC, HPLC, CE coupling ICP-AES Mass Spectrometers (Triple Quad, Orbitrap…) Atomic Fluorescence Electrochemical techniques (Polarography) Laser Ablation systems (Femtosecond et nanosecond) Sampling systems (automatic samplers) Cryogenic sampling system (gas sampling) Both ressources infrastructures makes it unique in Europe

Analytical Techniques ELECTROCHEMISTRY Polarography Titration MASS SPECTROMETER Orbitrap, UPLC, LC-MS-MS, SAMPLE PREP Microwave Heating plate CHROMATOGRAPHY HPLC, GC, EC ATOMIC SPECTROMETRY ICP-MS, ICP-AES, AFS, AAS ANALYTICAL RESSOURCES

Fields of expertise Determination of metals and metalloids in traces –Determination of the total concentration of trace elements in environmental, biological or industrial matrices Speciation Analyses –Determination of chemical forms of trace elements in environmental, biological or industrial matrices Characterization of the chemistry of industrial processes –Optimization of proceeded –Reduction of the volume of effluent –Determination of limiting factors Characterization of bio-molecules –Chemistry of metals and metalloids in the alive

Speciation analyses : « meeting point » ? ANALYTICAL CHEMISTRY AgribusinessEnvironment Industrial Hygiene Toxicology Law Regulation Process

Which sector fields Environment –Better approach of the impact of a pollution Pharmaceutics –Decision-making support on the efficiency of an active principle, a therapy Industry –Performances of a process of production, environmental policy, quality of a product Answers to the needs of analytical developments –Tributyltin in polymer matrices –Chromium VI in the sector of the surface treatment Realization by means of: Feasibility studies Analytical Subcontracting

Some examples : Environment Impact study on a lead pollution in an urban area –Speciation in soil, in air samples –Isotopic ratios (determination of the pollution source) Chromium (VI) speciation in atmospheric particles Control of the CRM stability (e.g. IRMM) Speciation of trace metals in gas and air particles from metal production unit and waste incinerator Trace metals in cooling water from nuclear plants Impact study of dredging activities in Arcachon bay (traces metals, TBT analyses) Mercury cycle in water treatment plant

Some examples : Agro-business, pharmaceutics Agro-business –Iodine determination in foodstuffs –Traces metals in vegetables and plants –Mercury and arsenic speciation in seafood and blood –Selenium speciation in food additives Pharmaceutics –Stability study of a platinum drug (in-vivo, in vitro studies) Validation and writing of an analytical method answering the specifications of the pharmacopoeia of the customer –Trace metal determinations in drugs

Some examples : Oil, Materials Oil –Ultra-traces metal analyses in crude oil (Cl, Si…) –Mercury speciation in gas condensates Materials –Traces metal in steel and polymers Contamination from catalysts (organotin compounds in plastics films, inks, glue…) Cr (VI) in steel and polymers –Direct analyse of solid by laser ablation Characterisation of multilayer materials P profile in cement

Training activities Annual training program –ICP-MS : 3 levels (Fundamental aspects, advanced, expert) –ICP-OES: general training –Sample preparation –Method validation –Speciation –Bio-molecules analyses (Mass spectrometry) –GC-MS –XRF –XPS (ESCA) Training on customer’s site Dedicated training sessions designed from customer’s requests

Our customers Analyses Laboratories and engineering offices –Environment Pharmaceutics and agro-business –R&D, drugs –Food Dietary food, produced complement, etc. Industrial processes –Surface treatments (Automobile)

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Distribution

Acknowledgements Ametek Spectro Courtage Analyses Service Atlantic Labo ICS Millipore European Union (Funds ERDF) Aquitaine Region Department of the Pyrénées Atlantiques City Community of Pau

Thank you for your attention ! UT2A Hélioparc Pau Pyrénées 2, Av. du Président Angot PAU Cedex 9 Tel/Fax: UT2A, The key of your analytical problems !