Summary of PK studies thru 10/1/04* * Samples analyzed thru 5/30/04
Immunosuppressant doses and Cmin after 2-4 weeks of rx
CsA Dosing by ARV and week CsA mg/dose NVPEFV1 PI2 PIkaletraNNRTI +PI NNRTI + kaletra Wk 2Wk 12Wk 28Yr 1Yr 2
Kaletra AUC by week pretx W2W12W28Y1Y2 efficacy LPVLPV + NNRTI LPV ng*h/mL RTVRTV + NNRTI RTV ng*h/mL
NFV NFV+NNRTI AUC ng*h/mL pretx W2W12W28Y1 efficacy NFV AUC by week M8/NFV AUC by week pretx21228yr 1yr 2 time AUC mcg*h/mL M8 NFV
NNRTI AUC by week NVP AUC ng*h/mL NVP NVP+ PI EFVEFV + PI EFV AUC ng*h/mL Wk 2 Wk 12Wk 28Yr 1Yr 2 pretx efficacy